73例乳腺黏液腺癌的临床特征及预后分析

发布时间：2018-03-08 01:10

  本文选题：乳腺黏液腺癌　切入点：临床特征　出处：《重庆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:探讨和分析乳腺黏液腺癌(MBC)的临床与病理特征和其对预后的影响。方法:回顾性分析73例乳腺黏液腺癌患者的临床资料、治疗方式、病理学特征。根据术后肿瘤病理将其分为单纯型乳腺黏液腺癌(PMBC)和混合型乳腺黏液腺癌(MMBC),结合临床资料和病理特征分析影响其预后因素。利用SPSS19.0软件统计分析黏液腺癌分子分型之间、PMBC和MMBC之间的特征差异。结果:73例乳腺黏液腺癌患者中PMBC共57例(占78.08%),MMBC共16例(占21.92%)。PMBC与MMBC在肿瘤大小、免疫组化指标等方面并无统计学差异。但MMBC比PMBC的腋窝腋窝淋巴结转移率更高(56.25%VS 7%),且差异有统计学意义(?2=17.461,P0.0001)。PMBC和MMBC的Ⅰ+Ⅱ期分别有52例(占98.1%)和11例(占68.2%),而Ⅲ期则分别为1例(占1.9%)和5例(占31.2%),两者有统计学差异(?2=9.904,P0.0020)。分子分型中Luminal A型38例(占57.58%),Luminal B型23例(占34.85%),HER-2过表达型1例(占1.37%),三阴型4例(占5.48%)。激素受体阳性的黏液腺癌与激素受体阴性之间比较,肿瘤大小、区域淋巴结转移等均未见有统计学差异。全组随访时间10~105个月,2例MMBC出现局部复发或远处转移,1例死亡,非乳腺癌相关死亡2例,其余均无瘤存活。结论:乳腺黏液腺癌具有相对惰性的生物学行为,激素受体阳性率高,腋窝淋巴结转移少见,肿瘤复发率低,预后好。病理亚型中单纯型乳腺黏液腺癌最为多见,分子分型主要以Luminal A型和Luminal B为主。腋窝淋巴结状况是MBC预后最为重要的因素。MMBC腋窝淋巴结转移率高于PMBC,且其预后相对较差。
[Abstract]:Objective: to investigate and analyze the clinical and pathological features of breast mucinous adenocarcinoma (MBC) and its influence on prognosis. Methods: the clinical data and treatment methods of 73 cases of breast mucinous adenocarcinoma were retrospectively analyzed. According to the pathological features, the tumor was divided into simple mammary mucinous adenocarcinoma (PMBCC) and mixed mammary mucinous adenocarcinoma (MMBC). The prognostic factors were analyzed by SPSS19.0 software combined with clinical data and pathological characteristics. Results among 73 cases of breast mucinous adenocarcinoma, 57 cases (78.08%) had PMBC and 16 cases (21.92%) had MMBC. There was no statistical difference in immunohistochemical markers, but the rate of axillary lymph node metastasis in MMBC was higher than that in axillary axillary lymph node of PMBC (56.25VS7T), and the difference was statistically significant. (2) there were 52 cases (98.1%) and 11 cases (68.2%) in stage 鈪，

本文编号：1581751