乳腺癌DCE-MRI量化参数与组织病理相关性分析

发布时间：2018-03-08 11:15

  本文选题：乳腺癌　切入点：磁共振成像　出处：《临床放射学杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的探讨基于动态增强磁共振成像(DCE-MRI)及特定药物动力学模型所获得的量化参数与乳腺癌组织病理相关性。方法搜集61例乳腺癌患者DCE-MRI资料,通过后处理软件生成如下量化参数,定量参数:转移常数(K~(trans))、速率常数(K_(ep))、血浆分数(V_p);半定量参数:(1)增强扫描病灶达峰时间(TTP);(2)增强扫描病灶内对比剂最大浓度值(MAX Conc);(3)增强扫描时间信号曲线下面积(AUC);(4)增强扫描时间信号曲线最大斜率值(MAX Slope)。所有患者MRI检查后1周内经手术或穿刺活检取得病理结果。采用Kruskal-Wallis检验及Mann-Whitney U检验两两比较导管内癌组,非特殊类型浸润性癌组及特殊类型癌组间各量化参数的差异。采用Mann-Whitney U检验分析低组织学分级组(包括Ⅰ级和Ⅱ级)和高组织学分级组(Ⅲ级)、有淋巴结转移组和无淋巴结转移组间各量化参数的差异。结果 61例乳腺癌分为导管内癌组8例,非特殊类型浸润性癌组48例,特殊类型癌组5例。导管内癌组量化参数值K~(trans) Max=0.651(0.209 min~(-1))、K_(ep) Max=0.865(0.198)min~(-1)、K_(ep) Mean=0.270(0.021)min~(-1)明显小于特殊类型癌组量化参数值K~(trans) Max=1.390(0.846)min~(-1)、K_(ep)Max=2.169(1.122)min~(-1)、K_(ep)Mean=0.512(0.449 min~(-1)),P值分别为0.025、0.020、0.038。非特殊类型浸润性癌组量化参数Ktrans Max=0.740(0.078)min~(-1)、K_(ep)Mean=0.235(0.023)min~(-1)及MAX Conc Max=0.188(0.013)小于特殊类型癌组间量化参数K~(trans) Max=1.390(0.846)min~(-1)、K_(ep) Mean=0.512(0.449)min~(~(-1))及MAX Conc Max=0.385(0.238),P值分别为0.043、0.025、0.036。非特殊类型浸润性癌组根据组织学分级,分为低组织学分级组(包括Ⅰ级和Ⅱ级)34例,高组织学分级组(Ⅲ级)12例。根据淋巴结转移状态,分为无淋巴结转移组37例,有淋巴结转移组24例,结果显示较低分化组与高分化组、无淋巴结转移组与有淋巴结转移组间各量化参数间差异无统计学意义。结论基于DCE-MRI技术及特定的药物动力学模型所获得的部分量化参数在乳腺癌不同病理类型间存在差异。
[Abstract]:Objective to investigate the correlation between the quantitative parameters obtained from dynamic enhanced magnetic resonance imaging (DCE-MRI) and specific pharmacokinetic models and the histopathology of breast cancer. Methods the DCE-MRI data of 61 patients with breast cancer were collected and the following quantitative parameters were generated by post-processing software. Quantitative parameters: transfer constant (K), rate constant (K), plasma fraction (V / P); semi-quantitative parameter (1) enhancement of peak time (TTP) / 2) enhancement of maximum concentration of contrast-medium in the lesion (Max Concor)) enhancement of the area under the scanning time signal curve and enhancement of the area under the scanning time signal curve (AUC ~ (4)). The maximum slope value of scanning time signal curve was Max Slope.The pathological results of all patients were obtained by operation or puncture biopsy within one week after MRI examination. Kruskal-Wallis test and Mann-Whitney U test were used to compare intraductal carcinoma group. Mann-Whitney U test was used to analyze the difference of quantitative parameters between non-special type invasive carcinoma group and special type carcinoma group. The low histological grade group (including grade 鈪，

本文编号：1583660