三阴性乳腺癌化疗后前瞻性记忆损害特征分析

发布时间：2018-03-09 05:22

本文选题：化疗　切入点：认知障碍　出处：《中华肿瘤防治杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的有关不同分子分型的乳腺癌患者化疗后前瞻性记忆(prospective memory,PM)损害是否存在差异,目前尚不清楚。本研究探讨三阴性乳腺癌(triple negative breast cancer,TNBC)患者化疗后基于事件的PM(event-based prospective memory,EBPM)与基于时间的PM(time-based prospective memory,TBPM)损害特征。方法收集2013-01-01-2015-09-30安徽医科大学第二附属医院肿瘤中心接受化疗的乳腺癌化疗后患者244例。其中TNBC 80例,非三阴性乳腺癌(non-triple negative breast cancer,NTNBC)164例。建立EBPM与TBPM的认知神经心理学试验范式,分别进行化疗前后的PM测查。结果与NTNBC患者相比,TNBC患者化疗后EBPM得分0.89±0.86,明显低于NTNBC组的2.59±0.90,差异有统计学意义,Z=-10.61,P0.01;TNBC和NTNBC患者化疗后TBPM得分别为4.65±0.83和4.80±0.92,差异无统计学意义,Z=-1.48,P0.05。结论乳腺癌患者化疗后存在不同程度的PM障碍,且TNBC较NTNBC患者EBPM损害更为显著。
[Abstract]:Objective to investigate whether there are differences in prospective memory (PM) damage in breast cancer patients with different molecular types after chemotherapy. It is not clear yet. This study was designed to investigate the characteristics of event-based PM(event-based prospective memory (EBPM) and time-based PM(time-based prospective (TBPM) damage in tri-negative breast cancer patients with triple negative breast cancer. Methods Cancer Center, second affiliated Hospital of Anhui Medical University, 2013-01-2015-09-30 was collected. #number0# patients with breast cancer received chemotherapy, including 80 patients with TNBC, Non-triple negative breast cancer in nontri-negative breast cancer. The cognitive neuropsychological test paradigm of EBPM and TBPM was established. Results compared with NTNBC patients, EBPM score was 0.89 卤0.86, which was significantly lower than that of NTNBC group (2.59 卤0.90). There was significant difference in TBPM score between NTNBC group and NTNBC group (4.65 卤0.83 and 4.80 卤0.92, respectively). Conclusion the patients with breast cancer have different degree of PM disorder after chemotherapy. EBPM damage in TNBC patients was more significant than that in NTNBC patients.
【作者单位】：安徽医科大学第二附属医院肿瘤中心;
【基金】：国家自然科学基金(81372487)
【分类号】：R737.9

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