RASAL2在乳腺癌中的表达及临床意义

发布时间：2018-03-09 11:25

  本文选题：乳腺癌　切入点：RASAL　出处：《安徽医科大学学报》2017年07期 　论文类型：期刊论文

【摘要】：应用免疫组织化学法检测60例乳腺癌组织及其癌旁组织中大鼠肉瘤蛋白活化因子2(RASAL2)的表达情况,分析RASAL2与乳腺癌临床发展及病理特征的相关性。结果显示,RASAL2在乳腺癌组织中的表达明显低于癌旁组织,差异有统计学意义(χ2=25.145,P0.001)。RASAL2在Luminal B型乳腺癌中的表达明显低于Non-Luminal B型,差异有统计学意义(χ2=4.319,P=0.038)。且RASAL2的表达与雌激素受体、孕激素受体、淋巴结转移、TNM分期和有无脉管侵犯有关(P0.05)。RASAL2在乳腺癌中低表达,且与乳腺癌的发展和侵袭转移有关。
[Abstract]:Immunohistochemical method was used to detect the expression of sarcoma protein activator 2 (RASAL2) in 60 cases of breast cancer and its adjacent tissues. The correlation between RASAL2 and clinical development and pathological features of breast cancer was analyzed. The results showed that the expression of RASAL2 in breast cancer tissues was significantly lower than that in adjacent tissues, and the difference was statistically significant (蠂 2 25. 145% P 0.001 +. RASAL2 expression in Luminal B breast cancer was significantly lower than that in Non-Luminal B breast cancer. The expression of RASAL2 was correlated with estrogen receptor, progesterone receptor, lymph node metastasis stage and vascular invasion in breast cancer, and the expression of RASAL2 was related to the development, invasion and metastasis of breast cancer.
【作者单位】： 安徽医科大学第二附属医院普外科;
【基金】：安徽省自然科学基金(编号:1308085QH152) 安徽医科大学校科研基金联合资助项目(编号:2015xkj111)
【分类号】：R737.9
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本文编号：1588320