糖尿病伴乳腺癌患者硫氧还蛋白结合蛋白、前列腺跨膜上皮抗原2、转录因子家族中成员GATA3的表达及血清氧化应激指标的变化

发布时间：2018-03-10 12:44

本文选题：乳腺癌　切入点：糖尿病　出处：《中国糖尿病杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的研究硫氧还蛋白结合蛋白(TXNIP)、前列腺跨膜上皮抗原2(STEAP2)、转录因子(GATA)家族中成员GATA3与糖尿病伴乳腺癌的关系,并分析患者术前及术后的血清氧化应激指标变化。方法检测45例糖尿病伴乳腺癌患者癌组织及对应癌旁组织中TXNIP、STAMP2、GAT.A3 mRNA表达量、蛋白水平及蛋白阳性表达情况,分析其临床病理特征,以及血清氧化应激指标的变化。结果乳腺癌组织中TXNIP mRNA、STAMP2 mRNA、GATA3 mRNA的相对表达量均下降(P0.05)。TXNIP、STAMP2、GATA3蛋白在乳腺癌组织中的表达低于癌旁正常组织(P0.05),且3个指标的表达阳性率为60%、66.7%、73.3%,均高于对应癌旁正常组织中的TXNIP蛋白表达阳性率(2.2%)(P0.05)。乳腺癌组织中TXNIP、STAMP2、GATA3蛋白表达阳性率均与分化程度、淋巴结转移与临床分级相关(P0.05)。患者术后血清MDA、髓过氧化物酶(MPO)均呈现先上升后下降变化趋势,SOD及总抗氧化力(TAC)呈现先下降后上升的变化趋势,术后6 d为转折点。结论 TXNIP、STAMP2、GATA3及血清氧化应激指标可能成为糖尿病伴乳腺癌患者诊断及治疗的参考指标。
[Abstract]:Objective to study the relationship between GATA3, a member of TXNIPP, transmembrane epithelial antigen 2STEAP2, transcriptional factor, and diabetes with breast cancer. Methods the expression of TXNIPP STAMP2GAT.A3 mRNA, protein level and protein expression in 45 patients with diabetes and breast cancer were detected. The clinicopathological features were analyzed. Results the relative expression of TXNIP mRNA-STAMP2 mRNA-GATA3 mRNA in breast cancer tissues was significantly lower than that in adjacent normal tissues (P0.05U. TXNIPP2mRNA-GATA3 protein), and the positive rate of the three markers was 6066.7mRNA-GATA3, and the positive rate of these three markers was 73.3in breast cancer tissues, and in breast cancer tissues, the relative expression of STAMP2 mRNA-GATA3 protein in breast cancer tissues was significantly lower than that in adjacent normal tissues (P 0.05), and the positive rate of these three markers was 73.3%. The positive rate of expression of TXNIP protein was higher than that of the normal tissues adjacent to the corresponding carcinoma (P 0.05). The positive rate of expression of TXNIP protein in breast cancer tissues was all higher than that in the corresponding normal tissues. The correlation between lymph node metastasis and clinical grade was P0.050.The serum MDAand myeloperoxidase (MPO) of the patients increased first and then decreased. Conclusion TXNIPMP2GATA3 and serum oxidative stress may be the reference indexes for the diagnosis and treatment of diabetic patients with breast cancer.
【作者单位】：重庆市急救医疗中心检验科;
【分类号】：R587.1;R737.9

【相似文献】