多发性骨髓瘤患者肺部感染的临床特点及相关因素分析

发布时间：2018-03-12 15:45

  本文选题：多发性骨髓瘤　切入点：肺部感染　出处：《中国感染与化疗杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的分析多发性骨髓瘤患者发生肺部感染的临床特点,以期为早期预防和临床诊疗提供理论依据。方法回顾性分析2012年1月-2015年4月收治住院的70例多发性骨髓瘤患者的相关资料,对患者的肺部感染临床表现及影像学特点、病原菌分布、感染相关因素进行分析。结果多发性骨髓瘤患者发生肺部感染时外周血白细胞计数和中性粒细胞比例可以表现为正常,红细胞沉降率明显增高,影像学提示以双肺感染较常见,常见病原菌是以铜绿假单胞菌为主的革兰阴性菌。发生肺部感染的易感因素主要是:粒细胞缺乏、Ⅲ期多发性骨髓瘤、合并症。结论多发性骨髓瘤患者发生肺部感染的临床症状多样;其易感因素主要是机体免疫力低下;常见病原菌是革兰阴性菌。在病原菌未检出前,经验性使用β内酰胺类-酶抑制剂复合制剂或喹诺酮类药物治疗可有效控制感染进展。
[Abstract]:Objective to analyze the clinical features of pulmonary infection in patients with multiple myeloma. Methods the data of 70 patients with multiple myeloma admitted from January 2012 to April 2015 were analyzed retrospectively, and the clinical manifestations and imaging features of pulmonary infection were analyzed. Results the leukocyte count and neutrophil percentage in peripheral blood of multiple myeloma patients with pulmonary infection were normal and the erythrocyte sedimentation rate was significantly increased. Imaging findings showed that bipulmonary infection was more common, and the common pathogens were gram-negative bacilli with Pseudomonas aeruginosa. The main risk factors for pulmonary infection were granulocytosis, stage 鈪，

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