血清睾酮水平预测前列腺癌骨转移的临床研究

发布时间：2018-03-12 19:35

本文选题：前列腺癌　切入点：骨转移　出处：《中华男科学杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的:本研究观察低血清睾酮水平是否能独立预测前列腺癌骨转移的风险。方法:本研究纳入标准为接受前列腺穿刺证实为前列腺癌,并进行骨扫描检测的患者165例,患者年龄58~78(66.6±5.3)岁。所有患者在诊断为前列腺癌之前未接受过雄激素剥夺治疗、化疗、放射治疗。我们收集患者的临床资料包括:年龄、前列腺穿刺Gleason评分、血清性激素、前列腺特异抗原(PSA)和碱性磷酸酶(ALP)水平,其中血清标本在前列腺穿刺之前的清晨收集。根据骨扫描结果,将前列腺癌分为骨扫描组和非骨扫描组,通过单因素分析筛选出有差异的因子,并进行了多因素非条件回归模型筛选出独立预测因子。结果:165例前列腺癌患者纳入本次研究,依据骨扫描结果分为前列腺癌骨转移组和非骨转移组。单因素分析结果显示年龄(P=0.126)、黄体生成素(P=0.930)、卵泡刺激素(P=0.763)和雌二醇(P=0.256)在两组之间并没有统计学差异,而血清PSA(P0.001)、前列腺穿刺的Gleason评分(P0.001)、血清睾酮(P=0.013)及血清碱性磷酸酶(P0.001)在预测骨转移有统计学意义。多因素分析结果显示低血清睾酮(P=0.531)、前列腺穿刺Gleason评分(P=0.898)并不能作为独立因子预测前列腺癌骨转移的风险,而血清碱性磷酸酶(P0.001,OR=1.018[1.011~1.026])和血清PSA(P0.001,OR=1.029[1.015~1.044])是有效的预测前列腺癌骨转移的风险因子。结论:低血清睾酮水平与前列腺癌骨转移密切相关,但不能成为有效的预测前列腺癌骨转移的风险因子。
[Abstract]:Objective: to investigate whether low serum testosterone levels can independently predict the risk of bone metastasis in prostate cancer. Methods: 165 patients with prostate cancer confirmed by prostate puncture and examined by bone scan were included in this study. All patients were not treated with androgen deprivation, chemotherapy, radiotherapy before diagnosis of prostate cancer. Our clinical data included age, prostate puncture Gleason score, serum sex hormone. Serum samples were collected early in the morning before prostate puncture. According to the results of bone scan, prostate cancer was divided into bone scanning group and non bone scanning group. Independent predictors were screened by univariate analysis and multivariate non-conditional regression model. Results: 165 prostate cancer patients were included in this study. Univariate analysis showed that there was no significant difference between the two groups in age (P < 0. 126), luteinizing hormone (P) 0. 930, follicle stimulating hormone (P) 0. 763) and estradiol (P) 0. 256). However, serum PSA-P0.001, Gleason score of prostate puncture P0.001, serum testosterone P0.013) and serum alkaline phosphatase P0.001) had statistical significance in predicting bone metastasis. Multivariate analysis showed that low serum testosterone P0. 531, prostate puncture Gleason score P0. 898) could not be used as a predictor of bone metastasis. Independent factors predict the risk of bone metastasis in prostate cancer. Serum alkaline phosphatase (P0.001) and serum PSAP 0.001 OR1.029 [1.0151.044] are effective risk factors for predicting bone metastasis of prostate cancer. Conclusion: low serum testosterone level is closely associated with bone metastasis of prostate cancer. However, it is not an effective risk factor for predicting bone metastasis in prostate cancer.
【作者单位】：九江学院;九江学院附属医院东院泌尿外科;南昌大学第一附属医院泌尿外科;
【基金】：江西省卫生和计划生育委员会科技支撑课题(20157083,20157084) 九江市支撑科技计划(20140024)~~
【分类号】：R737.25

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