硫酸钙人工骨联合同种异体骨与单纯人工骨治疗下肢良性骨肿瘤的对比研究

发布时间：2018-03-13 21:15

本文选题：硫酸钙　切入点：同种异体骨　出处：《第二军医大学学报》2017年12期 　论文类型：期刊论文

【摘要】：目的评价硫酸钙颗粒人工骨联合同种异体骨与单纯使用硫酸钙颗粒人工骨植骨治疗下肢良性骨肿瘤的效果。方法回顾性分析第二军医大学长海医院关节骨病外科2010年6月至2015年6月收治的符合研究条件的97例下肢良性骨肿瘤患者的临床资料,其中32例患者接受硫酸钙颗粒人工骨联合同种异体骨植骨治疗(联用组),另65例患者接受单纯硫酸钙颗粒人工骨植骨治疗(单用组)。比较并分析两组患者术后的切口不良事件、人工骨完全吸收后的骨质愈合情况等。结果联用组和单用组患者术后切口不良事件的发生率分别为15.6%(5/32)和26.2%(17/65),两组差异无统计学意义(P0.05)。联用组和单用组患者在硫酸钙颗粒人工骨完全吸收后,遗留明确或可疑骨缺损的发生率分别为9.4%(3/32)和29.2%(19/65),两组差异有统计学意义(P=0.028)。结论硫酸钙颗粒人工骨联合同种异体骨植骨治疗下肢良性骨肿瘤具有良好的效果,两者的联合使用不会增加切口不良事件的发生风险,并且可能降低人工骨被完全吸收后遗留骨缺损的风险。
[Abstract]:Objective to evaluate the effect of calcium sulfate granule artificial bone combined with allograft bone and calcium sulfate granulated artificial bone graft on benign bone tumor of lower extremity. Methods retrospective analysis was made on osteopathy surgery of joint in Changhai Hospital, second military Medical University. From June 2010 to June 2015, the clinical data of 97 patients with benign bone tumor of lower extremity were studied. 32 patients were treated with calcium sulfate granule artificial bone combined with allograft bone graft (combined group) and 65 patients received pure calcium sulfate granule artificial bone graft therapy (single use group). The adverse events of incision were compared and analyzed between the two groups. Results the incidence of postoperative incision adverse events in the combined group and the single group was 15.6- 5 / 32) and 26.2um / 17 / 65, respectively. There was no significant difference between the two groups (P 0.05). The patients in the combined group and the single group were treated with calcium sulfate. When the granular artificial bone was completely absorbed, The incidence of left clear or suspected bone defects was 9.4 / 32) and 29.20.19 / 65, respectively. The difference between the two groups was statistically significant (P < 0.028). Conclusion calcium sulfate granule artificial bone combined with allograft bone graft has a good effect in treating benign bone tumors of lower extremity. Combined use of the two methods does not increase the risk of adverse events and may reduce the risk of bone defects left over by the complete absorption of the artificial bone.
【作者单位】：第二军医大学长海医院关节骨病外科;福州总医院骨二科;第二军医大学长海医院创伤骨科;
【基金】：国家自然科学基金(81671199)~~
【分类号】：R738.1

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