合并肌少症肝细胞癌患者的临床病理特征及预后分析

发布时间：2018-03-14 22:09

  本文选题：癌　切入点：肝细胞　出处：《中国普通外科杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的:探讨合并肌少症肝细胞癌患者的临床病理特征及术后预后。方法:回顾性分析2010年3月—2016年6月期间就诊于武汉大学人民医院因肝细胞癌行肝切除术的139例患者的临床病理及随访资料。结果:139例患者中,56例(40.3%)合并肌少症。与非肌少症患者比较,肌少症患者体质量指数与骨骼肌指数明显降低、高TNM分期与微血管浸润比例明显增加(均P0.05);术后发生感染(14.3%vs.3.6%)、严重并发症(Clavien-Dindo Ⅲ级及以上)(19.6%vs.6.0%)、总并发症(35.7 vs.13.3%)的发生率明显升高(均P0.05);术后恢复时间(17.35 d vs.11.33 d)明显延长,需要入ICU治疗的患者比例(12.5%vs.2.4%)明显增加(均P0.05);术后总生存时间明显减少(P0.05)。Cox比例风险模型结果显示,合并肌少症是影响肝细胞癌患者术后生存的独立危险因素(P=0.001,HR=2.090,95%CI=1.340~3.259)。结论:合并肌少症的肝细胞癌患者术后并发症发率增加、恢复慢,且术后预后不良。
[Abstract]:Objective: to investigate the clinicopathological features and postoperative prognosis of hepatocellular carcinoma complicated with hypomyosis. Methods: a retrospective analysis of the patients undergoing hepatectomy for hepatocellular carcinoma in Renmin Hospital of Wuhan University from March 2010 to June 2016 was conducted. Results of 139 cases, 56 cases (40.3%) were complicated with hypothyroidism. Body mass index (BMI) and skeletal muscle index (BMI) were significantly decreased in oligocytopathic patients. The incidence of high TNM stage and microvascular infiltration was significantly increased (all P0.05; the incidence of postoperative infection was 14.3vs.3.6m; severe complications were Clavien-Dindo 鈪，

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