谷胱甘肽S-转移酶基因多态性与儿童急性淋巴细胞白血病遗传易感性的meta分析

发布时间：2018-03-14 22:38

  本文选题：急性淋巴细胞白血病　切入点：谷胱甘肽S-转移酶　出处：《中国实验血液学杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的:深入分析GST基因缺失与儿童ALL遗传易感性的关系。方法:基于纳入和排除标准计算机检索PubMed、Embase、相关期刊论文(CNKI)和万方数据库。检索时间截止至2015年8月,检索过程中无语言限制。采用STATA 12.0软件计算OR及其95%CI,敏感性分析验证结论的稳健性,漏斗图检测发表偏倚。结果:本研究共纳入27项病例和对照研究,包括3736例患者和5549例对照。Meta分析结果显示,GSTM1和GSTT1缺失基因型与儿童ALL之间的总OR值分别为1.41(95%CI:1.21~1.65)和1.26(95%CI:1.05~1.50),均较对照组显著降低,差异具有统计学意义(P=0.000,P=0.012)。在亚组分析中,黑种人群、亚洲人群、PB组(来自普通人的对照)、HB组(来自医院的对照)、"≥100病例数"组和"100病例数"组携带GSTM1基因突变的儿童发生ALL的风险显著增高。而对于GSTT1,其多态性仅与亚洲人群、PB组和"≥100病例数"组的发病风险有相关性。结论:GSTM1和GSTT1缺失基因型可能是儿童ALL的易感因素,但该结论有待进一步证实。
[Abstract]:Objective: to analyze the relationship between GST gene deletion and genetic susceptibility to ALL in children. Methods: PubMedMed Embase, CNKI and Wanfang databases were searched based on inclusion and exclusion standard computer. The search time was up to August 2015. STATA 12.0 software was used to calculate OR and its 95CI.The sensitivity analysis was used to verify the robustness of the conclusions, and funnel graph was used to detect publication bias. Results: 27 case and control studies were included in this study. Meta-analysis of 3736 patients and 5549 controls showed that the total OR values between GSTM1 and GSTT1 deletion genotypes and ALL in children were 1.41-95 CI: 1.211.65) and 1.2695 CI: 1.05C 1.50, respectively, which were significantly lower than those in the control group (P 0.000, P 0.012). The risk of developing ALL in children with GSTM1 gene mutation was significantly increased in Asian population (normal control group (control group from hospital, "鈮，

本文编号：1613283