ACLY在结肠癌组织中的表达及其临床意义

发布时间：2018-03-16 03:13

  本文选题：结肠癌　切入点：ATP柠檬酸裂解酶　出处：《东南大学学报(医学版)》2017年06期 　论文类型：期刊论文

【摘要】：目的:探索ATP柠檬酸裂解酶(ACLY)在结肠癌组织中的表达情况及其临床病理学意义,为结肠癌的诊治提供新思路。方法:以50例结肠癌患者为研究对象,用免疫组织化学染色方法观察结肠癌患者的癌组织及对应的癌旁组织标本中ACLY的表达,并研究ACLY表达的临床病理学意义。结果:在结肠癌组织中ACLY表达显著高于对应的癌旁组织(P=0);ACLY高表达与结肠癌的浸润深度、淋巴结转移及TNM分期显著相关(P值分别为0、0.005及0.007);与年龄、性别、肿瘤大小、组织分化程度无相关性(P0.05)。结论:ACLY在结肠腺癌组织中高表达,且与肿瘤转移相关;ACLY有望成为结肠癌诊治的一个新靶点。
[Abstract]:Objective: to explore the expression and clinicopathological significance of ATP citric acid lyase in colon cancer tissues, and to provide a new idea for the diagnosis and treatment of colon cancer. Immunohistochemical staining was used to observe the expression of ACLY in cancer tissues and adjacent tissues of patients with colon cancer. The clinicopathological significance of ACLY expression was studied. Results: the expression of ACLY in colon cancer tissues was significantly higher than that in the corresponding paracancerous tissues and the depth of invasion of colon cancer. There was no correlation between lymph node metastasis and TNM staging (P = 0. 005 and 0. 007), which was not correlated with age, sex, tumor size and tissue differentiation. ACLY associated with tumor metastasis is expected to be a new target for the diagnosis and treatment of colon cancer.
【作者单位】： 东南大学医学院;东南大学附属中大医院消化内科;
【分类号】：R735.35
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