副瘤性神经系统综合征的发病机制和临床诊断进展

发布时间：2018-03-17 07:22

  本文选题：副瘤性神经系统综合征　切入点：恶性肿瘤　出处：《重庆医科大学学报》2017年06期 　论文类型：期刊论文

【摘要】：副瘤性神经系统综合征(paraneoplastic neurological syndromes,PNS)是一种与恶性肿瘤密切关联的神经系统疾病,通常要排除其他原因。由于神经系统的每个层面均可受累,从而可导致神经系统的各部位损害出现广泛的神经系统症状和体征。自从发现特异性抗神经元胞核、胞浆及胞膜自身循环抗体后,对该病的认识及诊断得到很大提高,证实自身免疫作用导致PNS发生。本文就该病的临床表现、临床诊断标准、发病机制及癌肿与自身免疫的相关性作一阐述。
[Abstract]:Paraneoplastic neurological syndrome (PNS) is a nervous system disease closely associated with malignant tumors, usually excluding other causes. This may lead to extensive neurological symptoms and signs in various parts of the nervous system. Since the discovery of specific anti-neuronal nuclear, cytoplasmic and cytosolic autocirculatory antibodies, the recognition and diagnosis of the disease have been greatly improved. It is proved that autoimmune action leads to PNS. The clinical manifestation, clinical diagnostic criteria, pathogenesis and the correlation between autoimmunity and cancer are discussed in this paper.
【作者单位】： 蚌埠医学院第一附属医院神经内科;
【分类号】：R73;R747.9
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本文编号：1623744