食管癌诊断中代谢组学应用进展

发布时间：2018-03-21 09:41

本文选题：代谢组学　切入点：肿瘤　出处：《中华肿瘤防治杂志》2017年14期 　论文类型：期刊论文

【摘要】：目的食管癌在我国具有高发病率和高死亡率,找到早期筛查和诊断的方法是提高生存率的关键。代谢组学在肿瘤标志物的早期筛查中具有较为显著的优势。本研究总结代谢组学在食管癌早期诊断中的应用,探讨其发展方向和最新动态。方法以"代谢组学、肿瘤、食管癌和诊断"为关键词,检索PubMed以及CNKI期刊全文数据库截至2016-10发表的相关文献,共检索到英文文献108篇,中文文献46篇。纳入标准:(1)代谢组学相关研究;(2)食管癌的诊断。根据纳入标准分析文献23篇。结果食管癌患者和健康个体之间确实存在代谢轮廓差异。目前研究人员已经证明了血清代谢组学和尿液代谢组学应用于食管癌的诊断和分期的可行性,并筛选出一部分异常的小分子代谢物,包括胆碱磷酸、谷氨酸盐、肌醇、腺苷、缬氨酸和γ氨基丁酸等。结论食管癌代谢组学研究已取得可喜的进展,但因为代谢组学技术和检测仪器的局限,得到的食管癌发病相关代谢物还不全面,还需进一步提高检测手段,改进研究方法,使代谢组学发挥更大的作用。
[Abstract]:Objective esophageal cancer has high morbidity and mortality in China. Finding methods of early screening and diagnosis is the key to improve survival rate. Metabolomics has a significant advantage in early screening of tumor markers. This study summarized the application of metabolomics in early diagnosis of esophageal cancer. Methods with the key words of "Metabolomics, tumor, esophageal carcinoma and diagnosis" as the key words, the related literatures published in PubMed and CNKI Journal Full-text Database up to 2016-10 were searched, and 108 articles in English were retrieved. 46 articles were included in the study on Metabolomics. 23 articles were analyzed according to the inclusive criteria. Results there was a difference in metabolic profile between esophageal cancer patients and healthy individuals. The researchers have demonstrated the feasibility of using serum and urine metabonomics in the diagnosis and staging of esophageal cancer. Some small molecular metabolites, including choline phosphoric acid, glutamate, inositol, adenosine, valine and gamma-aminobutyric acid, were screened. However, due to the limitation of metabonomics techniques and detection instruments, the metabolites obtained from esophageal carcinogenesis are not comprehensive, so it is necessary to further improve the detection methods and research methods so as to make Metabolomics play a more important role.
【作者单位】：山东省医学科学院山东大学附属山东省肿瘤医院科教部;
【基金】：国家自然科学基金面上项目(81573246) 山东省自然科学基金培养项目(ZR2014HP044)
【分类号】：R735.1

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