蛋白酶激活受体2在骨癌疼痛发生发展中作用的研究进展

发布时间：2018-03-21 10:42

本文选题：蛋白酶激活受体　切入点：骨癌疼痛　出处：《山东医药》2017年47期 　论文类型：期刊论文

【摘要】：蛋白酶激活受体2(PAR2)是G蛋白偶联受体家族成员,由细胞内袢与C-末端、7个跨膜螺旋结构、N-末端与细胞外袢组成,广泛分布于各个组织系统,包括表皮、心血管、免疫系统、外周与中枢神经系统等,通过跨膜信号转导调节细胞的各种功能。骨癌疼痛大多数是由癌症转移到骨引起,常常伴随骨相关事件发生,严重影响患者生存质量。活化的PAR2通过调节相关的特殊信号通路,如P物质、降钙素基因相关肽、脑源性神经营养因子、瞬时感受器电位通道、丝裂原激活的蛋白激酶/细胞外信号调节激酶、N-甲基-D-天门冬氨酸受体、蛋白激酶A、蛋白激酶C、酟阿片受体等,参与骨癌疼痛痛觉敏化及痛觉信息的传递和调控。
[Abstract]:Protease activated receptor 2 (PAR2) is a member of the G protein-coupled receptor family. It is composed of intracellular loop and C-terminal, seven transmembrane helical structure N- terminal and extracellular loop. It is widely distributed in various tissue systems, including epidermis, cardiovascular and immune system. Peripheral and central nervous systems regulate cell functions through transmembrane signal transduction. Pain in bone cancer is mostly caused by the metastasis of cancer to the bone, often accompanied by bone related events. Activated PAR2 regulates specific signaling pathways, such as substance P, calcitonin gene-related peptide, brain-derived neurotrophic factor, transient receptor potential channel, and so on. Mitogen-activated protein kinase / extracellular signal-regulated kinase N-methyl-Daspartate receptor, protein kinase A, protein kinase C, opioid receptor participate in pain sensitization and the transmission and regulation of pain information in bone cancer.
【作者单位】：三峡大学医学院;
【基金】：国家自然科学基金资助项目(81503381)
【分类号】：R738

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