头孢西丁与他类抗菌药物在直肠癌患者手术部位术后感染中的效果及成本分析

发布时间：2018-03-22 11:03

本文选题：直肠癌　切入点：手术　出处：《中华医院感染学杂志》2017年24期 　论文类型：期刊论文

【摘要】：目的研究头孢西丁与他类抗菌药物在直肠癌患者术后手术部位感染中的运用效果及成本效果分析。方法选取2012年6月-2016年5月医院直肠癌手术患者124例,根据用药不同,将纳入的124例直肠癌手术患者分为A组、B组、C组、D组,每组各31例,A组给予注射用头孢西丁钠、B组给予注射用头孢唑林钠、C组给予注射用头孢美唑钠、D组给予注射用头孢他啶,比较四组患者术后发热率、手术部位感染率、愈合率、药物不良事件、治疗成本(直接成本、间接成本、隐形成本)、效价。结果 A组治疗总有效率为100.00%,高于B组的93.55%、C组的96.77%和D组的93.55%,但差异无统计学意义;A组、B组、C组和D组术后发热率、手术部位感染率比较差异无统计学意义;A组成本-效果比低于B组、C组和D组(P0.05)。结论头孢西丁相对其他类抗菌药物而言,在直肠癌手术部位感染中应用效果较好且经济实惠,是一种具有最小成本效果比值的优选方案,更具经济学价值,符合当前医保控费政策,有助于有限药物资源合理配置,降低患者经济负担、提高社会效益。
[Abstract]:Objective to study the effect and cost effect of cefxitin and other antimicrobial agents on postoperative surgical site infection in patients with rectal cancer. Methods 124 patients with rectal cancer were selected from June 2012 to May 2016. 124 patients undergoing rectal cancer surgery were divided into group A (n = 31) and group C (n = 31). Each group was given cefazolin sodium for injection (group C) and ceftazidime (group D) for injection. The postoperative fever rate, site infection rate, healing rate, adverse drug events, treatment cost (direct cost, indirect cost) were compared among the four groups. Results the total effective rate of treatment in group A was 100.00,96.77% in group C and 93.55% in group D, but there was no significant difference in the rate of postoperative fever between group A and group C and group D. There was no significant difference in the infection rate of surgical site between group A and group B.Conclusion compared with other antimicrobial agents, cefxitin has a better and more economical effect in the operation site infection of rectal cancer, which is lower than that in group B (group C) and group D (P 0.05). It is an optimal scheme with the minimum cost effect ratio, which has more economic value, accords with the current medical insurance fee control policy, and is helpful to the rational allocation of limited drug resources, the reduction of patients' economic burden and the improvement of social benefits.
【作者单位】：海南省中医院普外科;海口市人民医院胃肠外科;
【分类号】：R735.37

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