lncRNA调控膀胱癌干细胞上皮-间质转化机制的研究进展

发布时间：2018-03-24 11:09

本文选题：膀胱癌　切入点：长链非编码RNA　出处：《医学研究生学报》2017年02期

【摘要】：膀胱癌是泌尿系统中最常见的恶性肿瘤,具有易复发和转移的生物学特点。肿瘤干细胞(cancer stem cells,CSCs)理论解释了膀胱癌复发和转移的根源。上皮-间质转化(epithelial-mesenchymal transition,EMT)的发生可以促进肿瘤细胞获得干细胞特征,而具有干细胞特征的肿瘤细胞也相应的高表达EMT标记分子。长链非编码RNA(long noncoding RNA,lncRNA)通过调控肿瘤细胞的EMT过程,促进肿瘤细胞干性的产生和维持。CSCs、EMT和lncRNA共同参与调控肿瘤细胞的增殖、侵袭、转移等过程,与肿瘤的发生发展密切相关。阐明lncRNA与膀胱癌干细胞EMT的相互关系及其调控机制,将为膀胱癌复发和转移的靶向治疗提供新思路。文中对lncRNA调控膀胱癌干细胞EMT机制的最新研究进展进行综述。
[Abstract]:Bladder cancer is the most common malignant tumor in the urinary system. Tumor stem cell cancer stem cells explained the origin of recurrence and metastasis of bladder cancer. Epithelial-mesenchymal transition can promote tumor cells to acquire stem cell characteristics. Tumor cells with stem cell characteristics also express EMT marker molecules. Long chain noncoding RNA(long noncoding RNAs regulate the EMT process of tumor cells. To promote the production and maintenance of tumor cell dryness. CSCsMT-EMT and lncRNA are involved in the regulation of tumor cell proliferation, invasion and metastasis, and are closely related to the occurrence and development of tumor. The relationship between lncRNA and bladder cancer stem cell EMT and its regulatory mechanism are elucidated. It will provide a new idea for the targeted therapy of bladder cancer recurrence and metastasis. This paper reviews the latest research progress of lncRNA in regulating the EMT mechanism of bladder cancer stem cells.
【作者单位】：昆明医科大学第二附属医院泌尿外科云南省泌尿外科研究所云南省泌尿系统肿瘤工程实验室;
【基金】：云南省科技惠民计划项目(2014RA067) 云南省教育厅科学研究基金重点项目(2014Z052)
【分类号】：R737.14

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