多西紫杉醇或紫杉醇联合顺铂治疗老年晚期非小细胞肺癌的疗效比较

发布时间：2018-03-25 08:31

本文选题：非小细胞肺癌　切入点：多西紫杉醇　出处：《中国老年学杂志》2017年23期

【摘要】：目的探讨多西紫杉醇或紫杉醇联合顺铂治疗老年晚期非小细胞肺癌(NSCLC)的临床疗效及安全性。方法将86例晚期NSCLC患者按照化疗方法随机分为对照组(n=44)与实验组(n=42)。对照组采用紫杉醇联合顺铂进行治疗(紫杉醇150 mg/m~2,静脉滴注3 h,第1天,顺铂75 mg/m~2,静脉滴注第2,3天),实验组采用多西紫杉醇联合顺铂进行治疗(多西紫杉醇75 mg/m~2,静脉滴注1 h,第1天,顺铂75 mg/m~2,静脉滴注第2,3天),两组患者化疗2~4个周期。比较两组临床总有效率、中位生存时间及不良反应发生率。结果实验组和对照组客观有效27.27%和30.95%,两组无统计学差异(P0.05);实验组中位生存时间(11.8个月)明显高于对照组(8.9个月,P0.05);两组不良反应(中性粒细胞、血小板减少、血红蛋白减少、过敏、发热、感染、脱发、肝功能受损、肾功能受损、恶心呕吐、腹泻及感觉神经毒性)发生率均无统计学差异(P0.05)。结论多西紫杉醇联合顺铂组患者远期疗效优于紫杉醇组。
[Abstract]:Objective to investigate the clinical efficacy and safety of docetaxel or paclitaxel combined with cisplatin in the treatment of advanced non-small cell lung cancer (NSCLC) in elderly patients. The radiation group was treated with paclitaxel combined with cisplatin (paclitaxel 150 mg / mm2, intravenous drip for 3 h, day 1). The experimental group was treated with docetaxel combined with cisplatin (docetaxel 75 mg / mm2, intravenously for 1 hour, day 1). Cisplatin 75 mg / mm2, intravenous drip for 3 days, two groups of patients received 2 ~ 4 cycles of chemotherapy. The total effective rate of the two groups was compared. Results the objective effective rates of the experimental group and the control group were 27.27% and 30.955.There was no significant difference between the two groups (P 0.05), and the median survival time of the experimental group (11.8 months) was significantly higher than that of the control group (8.9 months), and the adverse reactions (neutrophil, neutrophil, neutrophil) in the two groups were significantly higher than those in the control group (P 0.05). Thrombocytopenia, hemoglobin reduction, allergy, fever, infection, alopecia, impaired liver function, impaired renal function, nausea and vomiting, There was no significant difference in the incidence of diarrhea and sensory neurotoxicity. Conclusion the long-term effect of docetaxel combined with cisplatin group is better than that of paclitaxel group.
【作者单位】：天津市海河医院胸外科;天津市海河医院肿瘤科;天津市海河医院药剂科;
【基金】：天津市卫生局科技基金项目资助(2011KZ078)
【分类号】：R734.2

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