自拟养正桂苓汤联合TP方案对卵巢癌的疗效及T细胞免疫功能的影响

发布时间：2018-03-28 06:33

本文选题：卵巢癌　切入点：养正桂苓汤　出处：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:观察自拟养正桂苓汤联合TP方案对卵巢癌的疗效及T细胞免疫功能的影响。方法:采用完全随机分组法将纳入的60例病例分为治疗组和对照组,其中对照组病例30例,予紫杉醇+顺铂化疗,治疗组病例30例,在西医化疗基础上配合服用自拟养正桂苓汤。化疗采用21天方案,连续观察2个周期,中药口服从化疗第一天开始,日2次各150ml早晚分服,连服6周。观察两组患者的中医证候积分、卡氏评分、肿瘤标志物CA125、T细胞免疫功能及血常规、肝肾功能等安全性指标。结果:1.中医疗效评定:治疗组总有效率为86.67%,对照组总有效率为60.00%,经统计p0.01,差异具有显著统计学意义。2.KPS评分:两组治疗后与治疗前比较,p值均小于0.0 1,差异具有显著统计学意义;且治疗后两组间比较,P=0.0020.01,差异具有显著统计学意义。3.肿瘤标志物CA125:两组治疗后与治疗前比较,p值均小于0.01,差异具有显著统计学意义;且治疗后两组间比较,p=0.0060.01,差异具有显著统计学意义。4.细胞免疫功能:两组治疗后与治疗前比较,p值均小于0.01,差异具有显著统计学意义;且治疗后两组间比较p0.01,差异具有显著统计学意义。5.在不良反应发生率上,两组在白细胞、谷丙转氨酶、谷草转氨酶及肌酐比较上,p均大于0.05,差异无统计学意义。结论:1.自拟养正桂苓汤联合TP方案能够降低卵巢癌患者血清CA125水平。2.自拟养正桂苓汤联合TP方案能够调节T细胞的表达水平,改善卵巢癌患者的免疫状态。3.自拟养正桂苓汤联合TP方案能够改善气虚血瘀型卵巢癌患者的临床症状,提高生活质量。
[Abstract]:Objective: to observe the effect of Yangzhenggui Ling decoction combined with TP regimen on ovarian cancer and T-cell immune function. Methods: 60 cases were randomly divided into treatment group and control group, including 30 cases in control group. Paclitaxel cisplatin chemotherapy was given. 30 cases in the treatment group were treated with self-made Yangzhenggui decoction on the basis of western medicine chemotherapy. The chemotherapy was carried out with a 21-day regimen and two consecutive cycles of observation. The oral administration of traditional Chinese medicine began on the first day of chemotherapy. 150ml was taken twice a day in the morning and evening for 6 weeks. The TCM syndromes score, Karschoff score, tumor marker CA125 T cell immune function and blood routine were observed in the two groups. Results: the total effective rate of the treatment group was 86.67, the total effective rate of the control group was 60.000.The difference was statistically significant (p0.01). 2. KPS score: the two groups were compared with the treatment group before and after treatment. The values were less than 0.01, the difference was statistically significant. The difference between the two groups after treatment was statistically significant (P < 0.01). The tumor marker CA125 was less than 0.01in both groups after treatment and before treatment, and the difference was statistically significant. After treatment, the difference between the two groups was statistically significant. 4. The cellular immune function: after treatment and before treatment, the P value of the two groups was less than 0.01, the difference was statistically significant. After treatment, the difference between the two groups was statistically significant. 5. In the incidence of adverse reactions, the two groups in white blood cells, alanine aminotransferase, Both glutamic oxaloacetic transaminase and creatinine were more than 0.05, the difference was not statistically significant. Conclusion: 1. The combination of Yangzhenggui Ling decoction and TP regimen can reduce the serum CA125 level of ovarian cancer patients .2.The self-made Yangzhenggui Ling decoction combined with TP regimen can adjust the level of serum CA125 in patients with ovarian cancer. The expression level of T cells, Improve the immune state of ovarian cancer patients .3.The combination of Yangzhenggui Ling decoction and TP regimen can improve the clinical symptoms and improve the quality of life of ovarian cancer patients with Qi deficiency and blood stasis type.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.31

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