磁小体的生物合成及用于肿瘤靶向治疗的研究进展

发布时间：2018-03-31 04:06

本文选题：磁小体　切入点：趋磁细菌　出处：《中国科学:生命科学》2017年05期

【摘要】：趋磁细菌产生的磁小体是生物膜包被的磁性纳米颗粒,具有优良的纳米磁特性;相比化学合成的磁性纳米材料,其生物来源赋予磁小体更好的生物相容性和遗传可操作性.在生物医学领域,除了用于磁热疗进行肿瘤治疗外,最近几年其作为靶向药物载体、可能参与肿瘤微环境调控的性质得到研究者的广泛关注;同时DNA重组技术的发展解决了磁小体的产率低而趋磁细菌难培养的问题.本文综述了磁小体的生物合成及其相关研究进展,并对其应用前景进行了展望.
[Abstract]:Magnetic bodies produced by magnetotactic bacteria are biofilm-coated magnetic nanoparticles with excellent nanomagnetic properties, compared with chemically synthesized magnetic nanomaterials, Its biological sources give magnetic bodies better biocompatibility and genetic maneuverability. In the biomedical field, in addition to magnetothermal therapy for cancer treatment, in recent years it has been used as a targeted drug carrier. The nature of possible involvement in the regulation of tumor microenvironment has been widely concerned by researchers. At the same time, the development of DNA recombination technology has solved the problem of low yield of magnetic bodies and difficult to culture magnetotactic bacteria. In this paper, the biosynthesis of magnetic bodies and their related research progress are reviewed, and the prospect of their application is prospected.
【作者单位】：山东大学生命科学学院山东大学-亥姆霍兹生物技术研究所微生物技术国家重点实验室;
【基金】：国家自然科学基金(批准号:31670097) 科技部国际合作专项(批准号:2015DFE32850) 山东省重点研发计划(批准号:2015GSF12101) 山东省重大专项(批准号:2015ZDJS04001)
【分类号】：R730.5

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