三个年龄段乳腺癌患者的临床病理特点分析

发布时间：2018-03-31 05:31

本文选题：乳腺癌　切入点：年龄　出处：《浙江大学》2015年博士论文

【摘要】：目的探讨不同年龄段乳腺癌患者的临床病理特点,为乳腺癌的个体化治疗提供更多依据。方法回顾性分析2014年3月至2015年2月期间就诊于浙江大学医学院附属第二医院肿瘤外科的316例原发女性乳腺癌患者的临床病理资料,将其分为青年组(39岁)、中年组(40-59岁)以及老年组(60岁)共三组。详细记录并分析三组患者的临床病理资料,包括但不限于肿块大小、淋巴结转移数、TNM分期、激素受体以及Ki67表达情况等,统计软件采用SPSS19.0中文版,统计方法采用χ2检验。结果三个年龄组乳腺癌患者在肿块大小、激素受体、病理类型中无差异,而在淋巴结转移数、TNM分期、组织学分级、分子分型以及Her2、Ki67表达水平中有差异。结论青年组乳腺癌患者淋巴结转移数、TNM分期、组织学分级、Her2过表达率、Ki67过表达率较其他组高,而Luminal A型占比较其他组低。
[Abstract]:Purpose. To explore the clinicopathological features of breast cancer patients in different age groups and to provide more evidence for individualized treatment of breast cancer. Method. The clinicopathological data of 316 primary female breast cancer patients from March 2014 to February 2015 in the second affiliated Hospital of Zhejiang University Medical College were retrospectively analyzed. They were divided into three groups: the young group (39 years old), the middle age group (40-59 years old) and the elderly group (60 years old). The clinicopathological data of the three groups were recorded and analyzed in detail, including, but not limited to, the size of the tumor, the number of lymph node metastasis and the TNM stage. The expression of hormone receptor and Ki67 were analyzed by SPSS19.0 Chinese version and 蠂 2 test. Results. There was no difference in tumor size, hormone receptor and pathological type among the three age groups, but there was no difference in TNM stage, histological grade, molecular type and expression level of Her2 + Ki67 in lymph node metastasis. Conclusion. In the young group, the number of lymph node metastases and the histopathological grade of Her2 overexpression rate of Ki67 were higher than those of other groups, but Luminal A was lower than that of other groups.
【学位授予单位】：浙江大学
【学位级别】：博士
【学位授予年份】：2015
【分类号】：R737.9

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