TRα1蛋白在甲状腺乳头状癌及结节性甲状腺肿的表达及临床研究

发布时间：2018-04-02 09:39

  本文选题：甲状腺乳头状癌　切入点：结节性甲状腺肿　出处：《新疆医科大学》2015年硕士论文

【摘要】：目的：通过对甲状腺乳头状癌和结节性甲状腺肿中TRα1蛋白表达量的测定,进一步研究甲状腺良恶性肿瘤的发病机制,并为其临床诊断、疾病鉴别、预后判断以及治疗方法提供指导。方法：选取新疆医科大学附第五附属医院经病理证实的2010年1月-2014年12月甲状腺乳头状癌及结节性甲状腺肿癌患者石蜡标本各50例,应用免疫组化(SP)法分别检测甲状腺乳头状癌和结节性甲状腺肿患者肿瘤组织中TRα1蛋白的表达以及伴淋巴结转移与无淋巴结转移甲状腺乳头状癌组织中TRα1蛋白的表达。结果：(1)TRα1蛋白阳性表达主要位于细胞核与细胞浆中；(2)TRα1蛋白在甲状腺乳头状癌阳性表达率为38.0%(19/50),结节性甲状腺肿中阳性表达率为84.0%(42/50),两者表达差异有统计学意义(P0.05)；(3)TRal蛋白在甲状腺乳头状癌中的表达与性别、年龄、肿瘤直径、病理分期差异均无统计学意义(P0.05)；而与淋巴结转移具有统计学意义(P0.05)；TRα1蛋白在结节性甲状腺肿中的表达与性别、年龄以及肿瘤直径之间的差异均无统计学意义(P0.05)。结论：(1)TRa 1蛋白有助于甲状腺乳头状癌与结节性甲状腺肿的诊断与鉴别诊断；(2)TRα1蛋白对于甲状腺乳头状癌的淋巴结转移、临床分期以及预后有预测作用。
[Abstract]:Objective: to study the pathogenesis of thyroid benign and malignant neoplasms by measuring the expression of tr 伪 1 protein in papillary thyroid carcinoma and nodular goiter.Prognostic judgment and treatment methods provide guidance.Methods: paraffin wax samples of 50 cases of papillary thyroid carcinoma and 50 cases of nodular goiter carcinoma confirmed by pathology in the Fifth affiliated Hospital of Xinjiang Medical University were selected.The expression of tr 伪 1 protein in thyroid papillary carcinoma and nodular goiter and the expression of tr 伪 1 protein in thyroid papillary carcinoma with and without lymph node metastasis were detected by immunohistochemical staining.Expression and sex of papillary thyroid carcinoma,There was no significant difference in age, tumor diameter and pathological stage (P 0.05), but there was no significant difference in the expression of tr 伪 1 protein with lymph node metastasis in nodular goiter and sex, the difference between age and tumor diameter was not significant (P 0.05).Conclusion the protein of TRA 1 protein is helpful to the diagnosis and differential diagnosis of papillary thyroid carcinoma and nodular goiter. TR 伪 1 protein can predict the lymph node metastasis, clinical stage and prognosis of papillary thyroid carcinoma.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R736.1
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本文编号：1699797