健脾温中汤对胃癌术后脾胃虚寒型患者的临床观察

发布时间：2018-04-08 17:35

本文选题：健脾温中汤　切入点：XELOX方案　出处：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:通过临床对照研究,观察健脾温中汤对胃癌术后脾胃虚寒型患者的肿瘤标志物(CEA、CA19-9、CA72-4)、临床症状、生活质量、化疗相关毒副反应发生率的改善情况,为运用中医药治疗胃癌术后辅助化疗方面积累一些临床经验。方法:将符合纳入标准的60例患者,随机分为对照组和治疗组。对照组30例,采取2周期XELOX(奥沙利铂+卡培他滨)方案化疗,治疗组30例,在行XELOX方案化疗同时,给予健脾温中汤,21天为一个治疗周期,连续观察2周期。观察两组患者治疗前后血清肿瘤标志物(CEA、CA19-9、CA72-4)变化、临床症状、生存质量及主要不良反应的情况。结果:治疗组在降低血清肿瘤标记物(CEA、CA19-9、CA72-4)、提高患者生存质量及改善临床症状方面与对照组比较有显著差异(P0.05)。不良反应方面,治疗组的白细胞(WBC)降低、血红蛋白(HB)降低及血小板(PLT)降低、恶心呕吐、腹泻发生率与对照组比较,有显著差异(P0.05);治疗组的肝肾功升高发生率、神经毒性发生率与对照组比较,差异无统计学意义(p0.05)。结论:1.健脾温中汤联合XELOX方案化疗可以使血清肿瘤标志物水平降低。2.健脾温中汤联合XELOX方案化疗可以明显改善患者临床症状,增加KPS评分,提高生存质量。3.健脾温中汤可以降低XELOX方案引起的骨髓抑制、恶心呕吐、腹泻的发生率。
[Abstract]:To accumulate some clinical experience on adjuvant chemotherapy after operation for treating gastric cancer with traditional Chinese medicine.Methods: 60 patients who met the inclusion criteria were randomly divided into control group and treatment group.30 patients in the control group were treated with XELOX (oxaliplatin capecitabine) regimen for 2 cycles, while 30 patients in the treatment group were treated with XELOX regimen chemotherapy and treated with Jianpi Wenzhong decoction for 21 days.The clinical symptoms, quality of life and main adverse reactions were observed before and after treatment.Results: there were significant differences between the treatment group and the control group in reducing the serum tumor marker CEA19-9 and CA72-4, improving the quality of life of the patients and improving the clinical symptoms of the treatment group compared with the control group (P 0.05).There was no significant difference in the incidence of neurotoxicity between the control group and the control group (p 0.05).Conclusion 1.Jianpi Wenzhong decoction combined with XELOX regimen can reduce serum tumor markers. 2. 2.Jianpi Wenzhong decoction combined with XELOX regimen chemotherapy can significantly improve the clinical symptoms of patients, increase the KPS score, improve the quality of life. 3.Jianpi Wenzhong decoction can reduce the incidence of bone marrow depression, nausea and vomiting, diarrhea caused by XELOX regimen.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.2

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