AGGF1和HIF-1α及VEGF表达与食管鳞癌放疗预后相关性研究

发布时间：2018-04-09 02:22

本文选题：食管鳞癌　切入点：AGGF1　出处：《新疆医科大学》2017年硕士论文

【摘要】：目的:食管鳞状细胞癌是一种比较常见的上消化道恶性肿瘤,放射治疗是食管鳞癌的主要治疗方法之一。本研究旨在探讨食管鳞癌组织中AGGF1和HIF-1α及VEGF的表达情况,及其与食管鳞癌的临床病理特征、放疗疗效及预后的关系。方法:该研究采用免疫组化SP法,检测新疆医科大学附属肿瘤医院胸腹放疗科2011-01-01—2015-01-01收治的79例食管鳞癌和20例正常食管组织中AGGF1、HIF-1α和VEGF的表达,结合临床病理特征和随访资料进行相关研究分析。结果:79例食管鳞癌中AGGF1(χ2=18.975,P0.001)、HIF-1α(χ2=26.884,P0.001)和VEGF(χ2=22.702,P0.001)的表达显著高于20例正常食管组织中的表达。食管鳞癌中AGGF1(χ2=8.134,P=0.004)和VEGF(χ2=5.175,P=0.023)的表达与淋巴结转移密切相关;HIF-1α的表达与临床分期(χ2=5.882,P=0.015)、淋巴结转移(χ2=7.712,P=0.005)和浸润深度(χ2=5.538,P=0.019)密切相关。食管鳞癌中VEGF和HIF-1α的表达呈正相关(r=0.333,P=0.003);AGGF1和VEGF的表达呈正相关(r=0.790,P0.001)。放疗近期疗效与HIF-1α的表达呈负相关(r=-0.246,P=0.029)。AGGF1(P=0.170)和VEGF(P=0.229)阳性表达组OS短于阴性组;HIF-1α阳性表达组OS显著短于阴性组(P=0.013)。Cox多因素回归分析显示,HIF-1α阳性表达(P=0.002)、浸润深度(P=0.005)和临床分期(P0.001)是食管鳞癌患者生存预后的影响因素。结论:AGGF1,HIF-1α及VEGF在食管鳞癌组织中高表达,并与食管鳞癌临床病理特征密切相关,三者高表达可能对食管鳞癌的放疗疗效和生存预后有影响,可为提高食管鳞癌的放疗效果和改善生存预后提供新的思路和方法。
[Abstract]:Objective: esophageal squamous cell carcinoma is a common malignant tumor of upper digestive tract, radiotherapy is one of the main treatment methods of esophageal squamous cell carcinoma.The purpose of this study was to investigate the expression of AGGF1, HIF-1 伪 and VEGF in esophageal squamous cell carcinoma and its relationship with the clinicopathological features, radiotherapy efficacy and prognosis of esophageal squamous cell carcinoma.Methods: immunohistochemical SP method was used to detect the expression of AGGF1HIF-1 伪 and VEGF in 79 cases of esophageal squamous cell carcinoma and 20 cases of normal esophageal tissues treated in Department of chest and abdominal radiotherapy, affiliated Cancer Hospital of Xinjiang Medical University, 2011-01-01-2015-01-01.Combined with clinicopathological features and follow-up data to carry out related research and analysis.Results the expression of AGGF-1 伪 and VEGF in 79 cases of esophageal squamous cell carcinoma were significantly higher than those in 20 normal esophageal tissues.There was a positive correlation between the expression of VEGF and HIF-1 伪 in esophageal squamous cell carcinoma.It is a prognostic factor of esophageal squamous cell carcinoma.Conclusion the high expression of HIF-1 伪 and VEGF in esophageal squamous cell carcinoma is closely related to the clinicopathological features of esophageal squamous cell carcinoma. The overexpression of these three proteins may have an effect on the radiotherapy efficacy and survival prognosis of esophageal squamous cell carcinoma.It can provide new ideas and methods for improving radiotherapy effect and survival prognosis of esophageal squamous cell carcinoma.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.1

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