锰增强磁共振成像诊断结直肠癌的初步实验研究

发布时间：2018-04-10 06:26

本文选题：结直肠癌　切入点：磁共振增强成像　出处：《临床放射学杂志》2017年01期

【摘要】：目的探讨锰增强磁共振成像(MEMRI)诊断结直肠癌的可行性。方法行结直肠癌细胞株SW620、DLD-1体外细胞摄锰磁共振成像检测,并以正常结肠黏膜上皮细胞为对照。行SW620、DLD-1细胞裸小鼠皮下移植,肿瘤最大径约5 mm、10 mm、15 mm时分别行磁共振成像。比较结直肠癌MEMRI与常规钆增强成像的表现,与病理对照。结果结直肠癌细胞株与正常细胞均摄取锰离子,癌细胞摄取更多。SW620、DLD-1摄锰后平均T1值缩短分别为正常细胞的4倍与2倍(P0.05)。大部分移植瘤(17/23)在MEMRI均明显强化。不论钆或锰增强病灶均为不均匀强化方式,但钆增强不明显的病灶在锰增强上均明显强化且强化范围增大。锰增强上5 mm组明显强化的肿瘤数较10 mm与15 mm组多。结论 MEMRI不仅能强化大多数结直肠癌,还能明显强化常规钆增强不明显的病灶。此外,MEMRI可能适于检出较小病灶。
[Abstract]:Objective to investigate the feasibility of manganese enhanced magnetic resonance imaging (MEMRI) in the diagnosis of colorectal cancer.Methods Human colorectal cancer cell line SW620 DLD-1 was detected by manganese magnetic resonance imaging in vitro, and normal colonic mucosal epithelial cells were used as control.SW620 DLD-1 cells were subcutaneously transplanted into nude mice, and Mr imaging was performed at the maximum diameter of 5 mm to 10 mm ~ 15 mm.To compare the findings of MEMRI and conventional gadolinium-enhanced imaging with pathology in colorectal cancer.Results both colorectal cancer cell lines and normal cells received manganese ion, and the mean T1 value of cancer cells was shortened by 4 times and 2 times than that of normal cells after manganese uptake by DLD-1, SW620 and DLD-1, respectively.Most of the transplanted tumors (17 / 23) were significantly enhanced in MEMRI.Both gadolinium and manganese enhanced lesions were non-uniform enhancement mode, but gadolinium enhancement was not obvious on manganese enhancement and the range of enhancement was increased.The number of enhanced tumors in the upper 5 mm group was more than that in the 10 mm and 15 mm groups.Conclusion MEMRI can not only enhance the majority of colorectal cancer, but also enhance the lesions with conventional gadolinium enhancement.In addition, MEMRI may be suitable for the detection of small lesions.
【作者单位】：昆明医科大学第一附属医院影像科;云南中医学院生理病理学教研室;昆明医科大学公共卫生学院;
【分类号】：R445.2;R735.3

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