吸烟对男性肺癌患者组织学分型的影响及其趋势分析

发布时间：2018-04-11 22:30

本文选题：肺肿瘤 + 吸烟史　；参考：《中国肺癌杂志》2017年08期

【摘要】：背景与目的已有的研究发现我国肺癌患者的组织学亚型分布有变化。本研究旨在探讨吸烟对我国男性肺癌患者组织学分型的影响及变化趋势。方法收集和整理2000年-2012年中国医学科学院肿瘤医院诊治的男性肺癌患者人口学、吸烟史、组织学等信息,用年度百分比变化(annual percentage change,APC)进行趋势检验。结果入选肺癌14,106例,其中吸烟11,750例,不吸烟2,356例。吸烟患者中,鳞癌的比例为39.38%,腺癌29.85%;2000年-2012年,鳞癌比例从44.19%下降至35.50%(APC=-1.9%,P0.001);腺癌从15.25%上升至41.85%(APC=6.8%,P0.001);腺鳞癌从4.13%降低至0.72%(APC=-14.9%,P0.001)。不吸烟患者中,腺癌53.86%,鳞癌16.64%;腺癌从38.03%上升至67.83%(APC=4.3%,P0.001);大细胞癌和腺鳞癌呈波动变化。结论肺腺癌在男性吸烟和非吸烟肺癌患者中的比例均显著上升,其非吸烟因素暴露与肺癌的关系应进一步深入研究。
[Abstract]:Background & AIM the distribution of histological subtypes in lung cancer patients has been found to change in China.The aim of this study was to investigate the effect of smoking on histological classification of male lung cancer patients in China.Methods demographic information, smoking history and histology of male lung cancer patients treated by Cancer Hospital of Chinese Academy of Medical Sciences from 2000 to 2012 were collected and analyzed.Results 14106 cases of lung cancer were selected, including 11750 cases of smoking and 2356 cases of non-smoking.In non-smoking patients, adenocarcinoma 53.86 and squamous cell carcinoma 16.64; adenocarcinoma increased from 38.03% to 67.83%; APC 4.3%; large cell carcinoma and adenosquamous carcinoma fluctuated.Conclusion the proportion of lung adenocarcinoma in male patients with both smoking and non-smoking lung cancer is significantly increased. The relationship between exposure to non-smoking factors and lung cancer should be further studied.
【作者单位】：国家癌症中心/中国医学科学院北京协和医学院肿瘤医院全国肿瘤防治研究办公室;
【基金】：北京希望马拉松基金项目(No.LC2008B47) 科技部国际合作专项(No.2010DFB34180)资助~~
【分类号】：R734.2

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