老年2型糖尿病血糖波动性及其与血清肿瘤标志物水平及结直肠癌的关系分析

发布时间：2018-04-13 12:41

本文选题：老年 + 型糖尿病　；参考：《广东医学》2017年21期

【摘要】：目的探讨老年2型糖尿病血糖波动性及其与血清肿瘤标志物水平及结直肠癌的关系。方法选取老年2型糖尿病患者165例为研究对象,对其结直肠癌发病情况及发生结直肠癌患者转移情况进行检测统计,行72 h动态血糖监测并取空腹静脉血进行血清肿瘤标志物水平检测。比较不同结直肠癌发病情况和转移情况、患者的血糖波动性和血清肿瘤标志物水平,采用Pearson线性相关分析法分析其血糖波动性与血清肿瘤标志物水平的关系,并采用Spearman分析法分析其血糖波动性与结直肠癌及其转移的关系。结果患者结直肠癌发生率及发生结直肠癌患者转移率分别为21.82%(36/165)和30.56%(11/36)。与无结直肠癌发生患者比较,有结直肠癌发生患者的血清癌胚抗原(CEA)、癌相关糖抗原199(CA199)和癌相关糖抗原242(CA242)等肿瘤标志物水平以及平均血糖波动幅度(MAGE)均升高(P0.05)。发生结直肠癌且出现转移患者的血清CEA、CA199和CA242水平和MAGE亦高于其无转移患者(P0.05)。Pearson线性相关分析法分析结果显示,老年2型糖尿病MAGE与其血清CEA、CA199和CA242等肿瘤标志物水平均呈正相关(r=0.796、0.842、0.815、P0.05)。Spearman分析法分析结果显示,老年2型糖尿病MAGE与其结直肠癌的发生及发生结直肠癌患者转移情况亦呈正相关(r=0.855、0.806,P0.05)。结论老年2型糖尿病血糖波动性与其血清肿瘤标志物水平及结直肠癌发生、发展均密切相关,严格控制血糖波动可能为老年2型糖尿病结直肠癌防治的有效措施之一。
[Abstract]:Objective to investigate the elderly type 2 diabetic blood glucose fluctuation and the relationship between the level and colorectal cancer with serum tumor markers. Methods 165 cases of elderly patients with type 2 diabetes as the research object, the incidence of colorectal cancer and node metastasis in patients with rectal cancer were detected for 72 h statistics, and dynamic monitoring of blood glucose in fasting blood the level of serum tumor markers detection. Compare the different incidence of colorectal cancer and metastasis, the blood glucose fluctuation and serum levels of tumor markers, using Pearson correlation analysis method to analyze the fluctuation of blood glucose and serum levels of tumor markers, and using Spearman analysis method to analyze the relationship between blood glucose fluctuation and colorectal cancer transfer. The results of patients with colorectal cancer and the incidence of colorectal cancer metastasis rate was 21.82% (36/165) and 30.56% (11/36) and free. Colorectal cancer patients with colorectal cancer, serum carcinoembryonic antigen (CEA), patients with cancer associated carbohydrate antigen 199 (CA199) and cancer associated carbohydrate antigen 242 (CA242) and tumor marker levels and average blood glucose fluctuation (MAGE) were increased (P0.05). The occurrence of colorectal cancer metastasis and serum CEA patients with CA199, and the level of CA242 and MAGE were also higher than that of the patients without metastasis (P0.05) analysis results.Pearson linear correlation analysis showed that elderly patients with type 2 diabetes MAGE and serum CEA, CA199 and CA242 were positively related to the level of tumor markers (r=0.796,0.842,0.815, P0.05).Spearman analysis showed that the incidence of colorectal cancer patients with metastasis was positively related to elderly patients with type 2 diabetes and colorectal cancer MAGE (r=0.855,0.806, P0.05). Conclusion elderly patients with type 2 diabetes blood glucose fluctuation and the level of serum tumor markers and colorectal cancer The development of cancer is closely related, and the strict control of blood glucose fluctuations may be one of the effective measures for the prevention and treatment of colorectal cancer in type 2 diabetes.

【作者单位】：广东药科大学附属第一医院胃肠外科;
【分类号】：R587.1;R735.34

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