子宫内膜癌组织中Elf5的表达变化及意义

发布时间：2018-04-14 04:11

本文选题：子宫内膜癌 + 抑癌基因　；参考：《山东医药》2017年45期

【摘要】：目的探讨Elf5在子宫内膜癌组织中的表达情况及其临床意义。方法选取子宫内膜癌组织84例份、子宫内膜不典型增生组织30例份和正常子宫内膜组织30例份,用免疫组化法检测Elf5在不同内膜组织中的表达情况,分析其与子宫内膜癌患者各临床病理指标的相关性;对所有子宫内膜癌患者进行术后随访,采用KaplanMeier进行生存分析,Cox比例风险回归模型进行子宫内膜癌多因素分析。结果 (1)子宫内膜癌组织Elf5阳性表达率低于正常子宫内膜组织及不典型增生子宫内膜组织(χ2分别为5.787、1.614,P均0.05);(2)Elf5的表达与FIGO分期、病理分级、病理类型、淋巴结转移和肌层浸润深度有关(P均0.05);(3)Kaplan-Meier生存分析显示,Elf5阴性表达患者的平均生存时间短于阳性表达患者(P0.05);(4)Cox回归分析显示FIGO分期、病理分级、肌层浸润深度、淋巴结转移及Elf5与子宫内膜癌患者预后有关(P均0.05),其中Elf5是子宫内膜癌患者预后的独立危险因素(P0.05)。结论子宫内膜癌组织中Elf5表达降低,其水平降低与子宫内膜癌发生发展及预后相关。
[Abstract]:Objective to investigate the expression of Elf5 in endometrial carcinoma and its clinical significance.Methods 84 cases of endometrial carcinoma, 30 cases of endometrial atypical hyperplasia and 30 cases of normal endometrium were selected to detect the expression of Elf5 in different endometrial tissues by immunohistochemistry.To analyze its correlation with the clinicopathological parameters of endometrial carcinoma, to follow up all patients with endometrial carcinoma after operation, and to analyze the multivariate factors of endometrial carcinoma by KaplanMeier survival analysis and Cox proportional risk regression model.Results (1) the positive expression rate of Elf5 in endometrial carcinoma was lower than that in normal endometrium and atypical hyperplasia endometrium (蠂 ~ 2 = 5.7871.614P, respectively). The expression of Elf5 in endometrial carcinoma was lower than that in normal endometrial tissue and atypical hyperplasia endometrium (蠂 ~ 2 = 0.05). The expression of Elf5 in endometrial carcinoma was correlated with FIGO stage, pathological grade and pathological type.The results of Kaplan-Meier survival analysis showed that the mean survival time of the patients with negative expression of Elf5 was shorter than that of the patients with positive expression (P 0.05). The regression analysis showed FIGO staging, pathological grade and depth of myometrial invasion.Lymph node metastasis and Elf5 were associated with prognosis in patients with endometrial carcinoma (P 0.05). Elf5 was an independent risk factor for the prognosis of endometrial carcinoma.Conclusion the decrease of Elf5 expression in endometrial carcinoma is related to the development and prognosis of endometrial carcinoma.
【作者单位】：徐州医科大学研究生学院;徐州医科大学附属医院;
【分类号】：R737.33

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