术前PLR、NLR对甲状腺乳头状癌患者术后无复发生存的预测价值

发布时间：2018-04-14 14:05

  本文选题：甲状腺乳头状癌 + 血小板/淋巴细胞比值　； 参考：《北京协和医学院》2015年硕士论文

【摘要】：目的：探究术前血小板／淋巴细胞比值(PLR)、中性粒细胞／淋巴细胞比值(NLR)对甲状腺乳头状癌无复发生存的预测价值。方法：回顾性分析1999年1月至1999年12月间在我院头颈外科经手术初治的135例甲状腺乳头状癌患者的临床资料,根据患者术前外周静脉血PLR、NLR值,采用ROC曲线,将病例资料分为低PLR组(PLR≤150)和高PLR组(PLR150)、低NLR组(NLR3)和高NLR组(NLR≥3),比较各组患者的15年无复发生存率,并采用Cox模型多因素分析,探究PLR、NLR是否为影响甲状腺乳头状癌术后无复发生存的独立危险因素。结果：1.低PLR组101例术后无复发生存率为83.4%,高PLR组34例术后无复发生存率为45.4%,低PLR组术后无复发生存率高于高PLR组术后无复发生存率,组间差异有统计学意义(X2=18.260,P0.001)2.低NLR组58例术后无复发生存率为85.7%,高NLR组77例术后无复发生存率为64.1%,低NLR组术后无复发生存率高于高NLR组术后无复发生存率,组间差异有统计学意义(X2=7.146,P=0.008)3.将单因素分析中有统计学意义(P0.05)的变量纳入Cox模型多因素分析可得,术前PLR、NLR是影响本组甲状腺乳头状癌术后复发的独立危险因素。结论：术前PLR、NLR对甲状腺乳头状癌患者术后无复发生存具有预测价值,两者均是便捷、经济的检测指标,在患者术前血常规分析中即可获得；既不增加患者负担,也可方便获取。PLR150或NLR≥3提示PTC患者预后较差,可以考虑作为PTC预后的判断指标,以期指导临床治疗。
[Abstract]:Objective: to investigate the prognostic value of preoperative platelet / lymphocyte ratio (PLR) and neutrophil / lymphocyte ratio (NLR) in the survival of papillary thyroid carcinoma without recurrence.Methods: the clinical data of 135 patients with papillary thyroid carcinoma treated in head and neck surgery between January 1999 and December 1999 were retrospectively analyzed. The ROC curve was used according to the peripheral venous blood of the patients before operation.The patients were divided into three groups: low PLR group (P < 150), high PLR group (n = 150), low NLR group (n = 3) and high NLR group (n = 3). The 15-year recurrence free survival rate of the patients in each group was compared, and the multivariate analysis of Cox model was used.To investigate whether PLRN-NLR is an independent risk factor for recurrence-free survival of papillary thyroid carcinoma.The result is 1: 1.The recurrence free survival rate in low PLR group was 83.4%, and that in high PLR group was 45.45.The recurrence free survival rate in low PLR group was higher than that in high PLR group. The difference between the two groups was statistically significant.The recurrence free survival rate was 85.7 in the low NLR group and 64.1 in the high NLR group. The recurrence free survival rate in the low NLR group was higher than that in the high NLR group. The difference between the two groups was statistically significant.The variables with statistical significance in univariate analysis (P0.05) were included in the multivariate analysis of Cox model. Preoperative Cox NLR was an independent risk factor for postoperative recurrence of papillary thyroid carcinoma.Conclusion: preoperative PLRV NLR has predictive value for postoperative recurrence free survival in patients with papillary thyroid carcinoma. Both of them are convenient and economical indexes, which can be obtained in preoperative blood routine analysis, and do not increase the burden of thyroid papillary carcinoma.It is also convenient to obtain. PLR150 or NLR 鈮，

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