经鼻蝶窦垂体瘤切除术对合并心肌病患者血清生长激素水平及心脏结构功能的影响分析

发布时间：2018-04-15 08:22

本文选题：垂体肿瘤 + 心肌增厚　；参考：《重庆医学》2017年36期

【摘要】：目的研究生长激素型垂体瘤合并心肌病患者外科手术治疗及临床疗效。方法选取该院2012年6月至2016年6月收治的65例生长激素型垂体腺瘤伴心肌病患者,所有患者均采取经鼻鼻蝶窦手术入路切除垂体瘤,观察术后2周血清生长激素水平、心电图结果、超声心电图结果及临床症状。结果术后患者体征均有明显改善,肢端肥大及鼻唇肥厚明显改善,头晕乏力、高血压及高血糖等均得到显著改善;术后平均生长激素水平为(4.37±2.03)μg/L,显著低于术前的(40.27±4.18)μg/L,差异有统计学意义(P0.01);患者术后的室间隔厚度(IVST)、左室舒张末期内径(LVIDd)和左室后壁厚度(LVPWT)均显著低于术前,差异有统计学意义(P0.01);患者术后的平均二尖瓣血流频谱(E/A)和左室射血分数(LVEF)明显低于术前,差异有统计学意义(P0.01)。结论经鼻蝶窦垂体瘤切除术能降低患者生长激素水平,改善心脏功能。
[Abstract]:Objective to study the surgical treatment and clinical effect of growth hormone pituitary adenoma complicated with cardiomyopathy.Methods Sixty-five patients with growth hormone type pituitary adenoma associated with cardiomyopathy were selected from June 2012 to June 2016. All the patients underwent transnasal sphenoid sinus surgery to remove pituitary adenoma, and the serum growth hormone levels were observed 2 weeks after operation.Results of electrocardiogram, ultrasonic electrocardiogram and clinical symptoms.Results the physical signs, acromegaly and nasolabial hypertrophy, dizziness and fatigue, hypertension and hyperglycemia were significantly improved.The postoperative mean growth hormone level was 4.37 卤2.03 渭 g / L, which was significantly lower than that before operation (40.27 卤4.18) 渭 g / L, the difference was statistically significant (P0.01), and the postoperative septal thickness (IVSTT), left ventricular end-diastolic diameter (LVIDD) and left ventricular posterior wall thickness (LVPWTs) were significantly lower than those before operation.The mean mitral flow spectrum (E / A) and left ventricular ejection fraction (LVEF) were significantly lower than those before operation (P 0.01).Conclusion Transsphenoidal pituitary adenectomy can reduce growth hormone level and improve cardiac function.
【作者单位】：苏州大学附属第一医院神经外科;
【基金】：国家自然科学基金资助项目(81671743)
【分类号】：R542.2;R736.4

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