Maspin在原发性胆管癌组织中的表达及其临床意义

发布时间：2018-04-16 17:34

本文选题：胆管肿瘤 + 丝氨酸蛋白酶抑制剂　；参考：《中国普通外科杂志》2017年08期

【摘要】：目的:探讨Maspin蛋白在原发性胆管癌中的表达和意义及其与p53蛋白的关系。方法:用免疫组化法检测42例胆管癌连同癌旁组织及12例正常胆管组织中Maspin蛋白和p53蛋白的表达,分析两者与患者临床病理因素及预后的关系以及两者之间的关系。结果:Maspin蛋白与p53蛋白在胆管癌组织中阳性率均明显高于癌旁组织与正常胆管组织(均P0.05);Maspin蛋白表达与胆管癌淋巴结转移及远处转移有关,而p53蛋白表达与胆管癌病理分级、TNM分期、淋巴结转移以及远处转移有关(均P0.05),但胆管癌中Maspin蛋白与p53蛋白表达无相关性(r=-0.329,P=0.144)。Maspin阳性表达患者术后生存期长于阴性表达患者(χ~2=4.440,P=0.035),而p53阳性表达患者术后生存期短于阴性表达患者(χ~2=8.231,P=0.004)。单因素与多因素Cox回归模型分析结果显示,Maspin蛋白是胆管癌患者预后的独立预测指标(HR=0.094,95%CI=0.015~0.593,P=0.012)。结论:Maspin蛋白在胆管癌组织中表达增加,但其减少或缺失可能与患者不良临床病理特征及预后密切相关,且其作用机制可能与p53蛋白无关联。
[Abstract]:Objective: To investigate the expression and significance of Maspin protein in primary bile duct carcinoma and its relationship with p53 protein. Methods: 42 cases of bile duct carcinoma and the expression of Maspin in tumor adjacent tissues and 12 cases of normal bile duct tissues and p53 protein by immunohistochemical method, to analyze the relationship between the relationship between them and clinical pathological factors and the prognosis and both. Results: Maspin protein and p53 protein in cholangiocarcinoma positive rate were significantly higher than those in adjacent tissues and normal bile duct tissues (P0.05); Maspin protein expression and metastasis of lymph node metastasis and distant bile duct carcinoma, and the expression of p53 protein in cholangiocarcinoma and pathological grading, TNM staging, lymph node lymph node metastasis and distant metastasis (P0.05), but the bile duct carcinoma Maspin protein was not correlated with p53 expression (r=-0.329, P=0.144).Maspin expression in patients with postoperative period is longer than the negative expression of patient survival (x ~2=4.440, P= 0.035), but the positive expression of p53 in postoperative patients with short survival in patients with negative expression (~2=8.231, P=0.004). Single factor and multi factor Cox regression model analysis showed that Maspin protein is an independent prognostic factor for patients with bile duct carcinoma (HR=0.094,95%CI=0.015~0.593, P=0.012). Conclusion: the expression of Maspin protein in cholangiocarcinoma increased but, the decrease or loss may be associated with adverse clinical pathological characteristics and prognosis are closely related, and its mechanism may not be associated with p53 protein.

【作者单位】：湖南省郴州市第一人民医院急诊科;中南大学湘雅医院普通外科;湖南省郴州市第一人民医院重症医学科;
【基金】：湖南省自然科学基金资助项目(2015JJ4049)
【分类号】：R735.8

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