胃神经内分泌癌临床病理特征及预后相关因素

发布时间：2018-04-17 20:24

本文选题：胃神经内分泌肿瘤 + 临床病理特征　；参考：《肿瘤》2017年10期

【摘要】：目的 :探讨胃神经内分泌癌(gastric neuroendocrine carcinoma,G-NEC)的临床病理特征及预后相关因素。方法:回顾性分析2009年1月—2015年9月在上海交通大学医学院附属仁济医院接受手术治疗的46例G-NEC患者的临床病理资料;结合术前检查、手术情况、病理诊断、术后化疗和随访结果,对患者的临床病理特征及预后相关因素进行分析。结果:单因素分析结果显示,年龄、Borrmann分型、肿瘤TNM分期和M分期、Ki-67指数、手术根治情况、肝转移、血清癌胚抗原水平、术后化疗是G-NEC的预后相关因素(P值均0.05)。多因素分析结果显示,年龄、手术根治情况、血清癌胚抗原水平、术后化疗是G-NEC预后的独立影响因素(P值均0.05)。结论:G-NEC是一类高度恶性的少见肿瘤,预后差。手术是否根治、术后是否进行化疗以及血清癌胚抗原水平与G-NEC患者的预后密切相关。
[Abstract]:Objective: to investigate the clinicopathological features and prognostic factors of gastric neuroendocrine carcinomatous G-NECs.Methods: the clinicopathological data of 46 patients with G-NEC received surgical treatment in Renji Hospital affiliated to Shanghai Jiaotong University Medical College from January 2009 to September 2015 were retrospectively analyzed.The clinicopathological features and prognostic factors of the patients were analyzed by postoperative chemotherapy and follow-up.Results: univariate analysis showed that age Borrmann classification, tumor TNM stage and M stage, Ki-67 index, radical operation, liver metastasis, serum carcinoembryonic antigen level, postoperative chemotherapy were the prognostic factors of G-NEC (P = 0.05).The results of multivariate analysis showed that age, radical operation, serum carcinoembryonic antigen level and postoperative chemotherapy were independent factors influencing the prognosis of G-NEC (P = 0.05).ConclusionTwo-G-NEC is a highly malignant and rare tumor with poor prognosis.Postoperative chemotherapy and serum carcinoembryonic antigen level were closely related to the prognosis of patients with G-NEC.
【作者单位】：上海交通大学医学院附属仁济医院肿瘤科;上海交通大学医学院附属仁济医院病理科;
【基金】：上海高校青年教师培养资助计划基金资助项目(编号:ZZjdyx13063)~~
【分类号】：R735.2

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