西黄胶囊防治急性放射性口腔黏膜炎的疗效及相关机制

发布时间：2018-04-19 15:02

  本文选题：西黄胶囊 + 放射性口腔黏膜炎　； 参考：《中成药》2017年06期

【摘要】：目的探讨西黄胶囊(人工牛黄、人工麝香、乳香、没药)对急性放射性口腔黏膜炎的防治作用及相关机制。方法将80例接受根治性放疗的鼻咽癌患者随机分为2组,给药组(照射+西黄胶囊)和对照组(单纯照射)。依据急性放射性黏膜损伤分级标准比较2组开始出现黏膜炎的时间和耐受剂量。并用ELISA法检测唾液炎性因子TNF-α和IL-6水平。结果与单纯照射组比较,给药组出现黏膜炎时间明显偏晚,放疗耐受剂量显著偏高(t=2.180、12.930,P0.05);DT=40、70 Gy时,给药组Ⅲ、Ⅳ度口腔黏膜炎发生率均低于单纯照射组(Z=3.661、4.270,P0.01);放疗前(DT=0 Gy),2组炎性因子TNF-α和IL-6质量浓度无差别(t=1.010、1.469,P0.05);炎性因子水平随着放疗剂量的增加而升高,DT=40 Gy时达峰值,但给药组TNF-α和IL-6质量浓度均显著低于单纯照射组(t=8.305、6.069,P0.05);DT=70 Gy时,炎性因子均降至低于治疗前水平且给药组明显低于单纯照射组(t=3.835、2.488,P0.05)。结论西黄胶囊能够延缓并减轻急性放射性口腔黏膜炎,提高放疗耐受剂量,可能与抑制炎性介质TNF-α和IL-6的释放有关。
[Abstract]:Objective to investigate the preventive and therapeutic effects of Xihuang capsule (artificial bezoar, artificial musk, frankincense, myrrh) on acute radioactive oral mucositis.Methods 80 patients with nasopharyngeal carcinoma receiving radical radiotherapy were randomly divided into two groups: the control group and the control group.According to the classification criteria of acute radiation mucosal injury, the time and tolerance dose of mucositis were compared between the two groups.The levels of TNF- 伪 and IL-6 were detected by ELISA.Results compared with the irradiation group, the time of mucositis in the administration group was obviously late, the dose of radiation tolerance was significantly higher than that in the control group, and the dosage of radiation tolerance was significantly higher than that in the control group.The incidence of oral mucositis in grade 鈪，

本文编号：1773575