3.0T磁共振质子波谱成像评价吉西他滨联合黄芪多糖注射液治疗胰腺癌模型兔的研究

发布时间：2018-04-20 01:27

  本文选题：磁共振质子波谱成像 + 吉西他滨　； 参考：《中国中西医结合杂志》2017年08期

【摘要】：目的观察3.0T磁共振质子波谱成像评价吉西他滨联合黄芪多糖注射液治疗胰腺癌模型的效果。方法选取家兔60只成功制备胰腺癌模型,采用随机数字表法分为治疗1组、治疗2组及对照组,每组20只。治疗1组家兔给予尾静脉注射多西他滨联合黄芪多糖注射液,治疗2组家兔给予尾静脉注射多西他滨注射液,对照组家兔同期给予生理盐水等量注射,共治疗2周。对3组家兔同时行3.0T磁共振质子波谱成像检查,选择单体素点分辨波谱(PRESS)序列,分析波谱成像中代谢物的表现,比较3组家兔代谢物峰显示率并计算胆固醇与不饱和脂肪酸的混合峰(Chol+Unsat)与脂肪峰(Lip)峰高的比值(Chol+Unsat/Lip)。结果 3组家兔磁共振质子波谱成像主要代谢峰包括Lip峰、Chol+Unsat峰及胆碱峰(Cho),3组家兔Cho峰显示率比较,差异无统计学意义(P0.05);对照组(Chol+Unsat)/Lip值为0.316±0.125,治疗1组(Chol+Unsat)/Lip值为0.224±0.095,治疗2组(Chol+Unsat)/Lip值为0.267±0.101,治疗1组、治疗2组分别与对照组比较,差异均有统计学意义(P0.05),治疗1组与治疗2组比较,差异亦有统计学意义(P0.05)。结论吉西他滨联合黄芪多糖注射液对胰腺癌模型具有较好的治疗效果,采用3.0T磁共振质子波谱成像可通过对代谢物波谱表现等指标评估胰腺癌模型的治疗效果。
[Abstract]:Objective to evaluate the therapeutic effect of gemcitabine combined with astragalus polysaccharide injection on pancreatic carcinoma model by 3.0T magnetic resonance proton spectrum imaging. Methods 60 rabbit models of pancreatic cancer were selected and randomly divided into treatment group (n = 20), treatment group (n = 20) and control group (n = 20). In the first group, doxitabine and astragalus polysaccharide injection were injected into the tail vein of the rabbits in the first group. The rabbits in the treatment group were given the doxitabine injection in the tail vein and the control group were given the same amount of normal saline for 2 weeks. Three groups of rabbits were examined by 3.0T magnetic resonance proton spectroscopy (MRI) simultaneously, and monomeric point-resolved spectral spectroscopy (PRESS) sequence was selected to analyze the metabolites in spectral imaging. The peak display rate of metabolites in the three groups was compared and the ratio of Chol Unsatt / lipid peak height of cholesterol and unsaturated fatty acids was calculated. Results the main metabolic peaks of proton magnetic resonance spectroscopy (PSRS) in the three groups included Lip peak Chol Unsat peak and choline peak Cho Cho group. The display rate of Cho peak was compared among the three groups. There was no significant difference in Unsat)/Lip between control group (0.316 卤0.125), treatment group (0.224 卤0.095), treatment group (0.267 卤0.101), treatment group (group 1) and control group (P 0.05). The difference was also statistically significant (P 0.05). Conclusion gemcitabine combined with astragalus polysaccharide injection has a good therapeutic effect on pancreatic cancer model. Using 3.0T proton magnetic resonance spectroscopy imaging, the therapeutic effect of pancreatic cancer model can be evaluated by the index of metabolite spectrum.
【作者单位】： 齐齐哈尔医学院医学技术学院;齐齐哈尔医学科学院蛋白质结构与功能研究室;齐齐哈尔医学院附属第三医院MR室;
【基金】：黑龙江中医药中青年科技攻关项目(No.ZQG-077) 齐齐哈尔医学院院内科研基金资助项目(No.QY2016M-06)
【分类号】：R-332;R735.9
，

本文编号：1775634