动态增强磁共振与乳腺癌不同分子亚型血管生成的相关性研究

发布时间：2018-04-20 17:59

本文选题：乳腺癌 + 分子亚型　；参考：《济南大学》2016年硕士论文

【摘要】：目的探讨动态增强磁共振(DCE-MRI)半定量的参数早期增强率(EER)、达峰时间(TTP)、最大线性斜率(SLOPE)与乳腺癌不同分子亚型血管生成的相关性,及比较乳腺癌不同分子亚型血管生成的特点。资料和方法2012-12-01—2015-03-31经手术确诊的103例乳腺癌患者,术前一周内行DCE-MRI扫描,记录上述参数,对切除病变行常规病理和免疫组化检查,根据免疫组化结果分为四种不同分子亚型,观察微血管密度(MVD)计数和血管内皮生长因子(VEGF)的表达,并将不同分子亚型DCE-MRI各项参数与免疫组化结果进行相关性分析。结果四种不同分子亚型的各动态增强参数没有显著性差异;三阴型乳腺癌MVD(79.47±49.79)明显高于Luminal B型(50.89±18.21),P值为0.02;除了Luminal A型与Luminal B型之外,其他各亚型之间VEGF表达均有差异(P0.001);三阴型乳腺癌的MVD与DCE-MRI的关系最密切,MVD与EER、SLOPE呈正相关,相关系数分别为r=0.55(P=0.0015),r=0.859(P0.001),与TTP呈负相关,相关系数r=-0.60(P=0.007)。Luminal A型乳腺癌MVD与EER、SLOPE呈正相关,相关系数分别为r=0.71(P0.001),r=0.51(P=0.001),Luminal B型MVD与EER、SLOPE的相关系数分别为r=0.38(P=0.016),r=0.39(P=0.023)。结论三阴型乳腺癌较Luminal B表现为更丰富的血管生成,三阴型及Luminal型MVD与DCE-MRI半定量参数EER、SLOPE存在一定的相关性。
[Abstract]:Objective to investigate the correlation between dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) semi-quantitative parameter early enhancement rate (EERA), peak peak time (TTP), maximum linear slope (SLOPE) and angiogenesis of different molecular subtypes of breast cancer, and to compare the characteristics of different molecular subtypes of angiogenesis in breast cancer. Materials and methods 103 patients with breast cancer diagnosed by operation from 2012-12-01-2015-03-31 were examined with DCE-MRI within one week before operation. The above parameters were recorded. The pathological changes were examined by routine pathology and immunohistochemical examination. According to the immunohistochemical results, the patients were divided into four different molecular subtypes. The microvessel density (MVD) count and the expression of vascular endothelial growth factor (VEGF) were observed. The correlation between the parameters of different molecular subtypes of DCE-MRI and the immunohistochemical results was analyzed. Results there was no significant difference in dynamic enhancement parameters among the four different molecular subtypes, the MVD(79.47 卤49.79 of three negative type breast cancer was significantly higher than that of Luminal B type (50.89 卤18.21% P = 0.02), except Luminal A type and Luminal B type. There were significant differences in VEGF expression among other subtypes (P 0.001), the relationship between MVD and DCE-MRI was most closely related to DCE-MRI, and the correlation coefficients were 0.55 P0. 55 P0. 0015 P 0. 859 P 0. 001, which were negatively correlated with TTP, and MVD of r=-0.60(P=0.007).Luminal A breast cancer were positively correlated with EERLSLOPE, and the correlation coefficients were 0. 05%, 0. 05%, 0. 05% and 0. 05% P 0. 001, respectively, and there was a positive correlation between MVD and EERSLOPE. The correlation coefficients between the two types of MVD and EERSS-SLOPE were 0.71 ~ 0.71 and 0.39 ~ 0.39 ~ (0.39) ~ 0. 023 ~ 2 ~ (-1), respectively. The correlation coefficients of the two types of MVD and EEROPE were 0.71 and 0.31, respectively, and the correlation coefficients were 0.39 (0.39) and 0.023 (P = 0.023), respectively. Conclusion Tri-negative breast cancer is more abundant in angiogenesis than that of Luminal B. MVD of tri-negative type and Luminal type has some correlation with DCE-MRI semi-quantitative parameter EER-SLOPE.
【学位授予单位】：济南大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R737.9

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