PDE4B基因过表达对弥漫大B细胞淋巴瘤患者的预后价值

发布时间：2018-04-21 14:07

本文选题：环核苷酸磷酸二酯酶类 + 型　；参考：《中华疾病控制杂志》2017年05期

【摘要】：目的探讨磷酸二酯酶4B(phosphdiesterase 4B,PDE4B)基因过表达对弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)患者预后的影响,并分析其预后价值。方法从GEO(gene expression omnibus)数据库获得320例DLBCL患者的基因芯片数据,比较PDE4B基因过表达与正常表达患者生存率的差异。构建单变量国际预后指数(international prognostic index,IPI)、PDE4B和多变量(IPI+PDE4B)Cox比例风险模型,并用时点/动态受试者工作曲线(receiver operating characteristic curves,ROC)法分析模型的预测能力随时间的变化趋势,一致性统计量C用于评价和比较各模型的预测准确度。结果 PDE4B基因过表达的患者死亡的风险是正常表达的1.431倍(HR=1.431,95%CI:1.013~2.002,P=0.042)。多变量模型的C统计量与单变量模型相比,差异有统计学意义(IPI vs.IPI+PDE4B:Z=15.0,P0.001;PDE4B vs.IPI+PDE4B:Z=53.7,P0.001)。结论 PDE4B基因过表达是DLBCL患者预后的危险因素,结合IPI和PDE4B基因能提高DLBCL的预后准确性。
[Abstract]:Objective to investigate the effect of the overexpression of phosphodiesterase 4B(phosphdiesterase 4BmP PDE4B gene on the prognosis of diffuse large B-cell lymphoma (DLBCL) patients with diffuse large B-cell lymphoma (DLBCL), and to analyze its prognostic value. Methods the microarray data of 320 patients with DLBCL were obtained from GEO(gene expression omnibus database. The survival rates of patients with PDE4B overexpression and normal expression were compared. The international prognostic index IPE4B and multivariate PDE4B)Cox proportional risk model were constructed. The prediction ability of the model was analyzed by using the time-point / dynamic receiver operating characteristic curvesroc method. Consistency statistic C is used to evaluate and compare the prediction accuracy of each model. Results the risk of death in patients with overexpression of PDE4B gene was 1.431 times higher than that in normal expression. Compared with the single variable model, the C statistic of multivariate model has statistical significance. The difference of IPI vs.IPI PDE4B: Z0. 001n PDE4B vs.IPI PDE4B: P0.001is significant. Conclusion overexpression of PDE4B gene is a risk factor for the prognosis of patients with DLBCL. The combination of IPI and PDE4B genes can improve the prognosis accuracy of DLBCL.
【作者单位】：山西医科大学公共卫生学院卫生统计教研室;山西省肿瘤医院病理科;
【基金】：国家自然科学基金(81473073)
【分类号】：R733.1

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