三阴性乳腺癌化疗相关认知障碍与年龄的相关性研究

发布时间：2018-04-22 04:01

本文选题：乳腺癌 + 化疗相关认知障碍　；参考：《安徽医科大学学报》2017年01期

【摘要】：目的探讨三阴性乳腺癌化疗相关认知障碍(CICI)与年龄的相关性。方法纳入不同年龄段乳腺癌化疗患者和健康对照组各90例,其中三阴性乳腺癌(三阴组)及非三阴性乳腺癌(非三阴组)各45例,分为青年、中年、老年组各30例,其中三阴组、非三阴组各年龄分组均为15例。分别进行简易精神状态检查表(MMSE)及回顾性记忆(RM)和前瞻性记忆(PM)问卷调查。结果乳腺癌组与健康对照组MMSE、RM量表、PM量表评分相比差异均有统计学意义(P0.000 1)。乳腺癌组中,MMSE评分与年龄呈负相关性(r=-0.675,P0.000 1),RM量表、PM量表评分与年龄呈正相关性(r=0.500、0.429,P0.000 1)。三阴组、非三阴组在MMSE、RM量表、PM量表中差异均有统计学意义(P0.05)。三阴组、非三阴组中,其青年组、中年组、老年组3组间MMSE、RM量表、PM量表评分差异均有统计学意义(P0.000 1)。在青年组中,三阴组与非三阴组相比,MMSE、RM量表、PM量表评分差异均有统计学意义(P0.000 1)。而中、老年组中,三阴组与非三阴组相比,MMSE、PM量表、RM量表评分差异均无统计学意义。多元Logistic回归分析结果显示:三阴性乳腺癌(OR=3.763,P=0.005)、年龄(OR=1.097,P0.000 1)为乳腺癌患者发生认知障碍的危险因素。结论乳腺癌化疗患者均出现不同程度的认知障碍,与非三阴性乳腺癌患者相比,三阴性乳腺癌患者认知障碍较严重,其差异主要以青年患者为主,同时三阴性乳腺癌与年龄均为乳腺癌CICI的危险因素。
[Abstract]:Objective to investigate the correlation between cognitive impairment of chemotherapy associated with three negative breast cancer (CICI) and age. Methods included 90 cases of breast cancer chemotherapy in different age groups and healthy control group, including three negative breast cancer (three yin group) and 45 non three negative breast cancer (non three yin group), which were divided into young, middle-aged, and old group 30, three yin group, and non three. There were 15 cases of all age groups in the Yin group. The simple mental state Checklist (MMSE), retrospective memory (RM) and prospective memory (PM) questionnaire were conducted respectively. The results were statistically significant (P0.000 1) compared with the MMSE, RM scale and PM scale score in the breast cancer group and the healthy control group (P0.000 1). The MMSE score was negatively correlated with age in the breast cancer group (r=-0.). 675, P0.000 1), RM scale, PM scale score and age positive correlation (r=0.500,0.429, P0.000 1). Three negative group, RM scale, RM scale, PM scale difference were statistically significant (P0.05). Three yin group, non three yin group, the young group, middle age group, old year group 3 groups MMSE, RM scale, PM scale scores were statistically significant differences 1). In the young group, compared with the non three yin group, the difference of MMSE, RM and PM was statistically significant (P0.000 1). In the elderly group, the three yin group and the non three yin group were compared with the non three yin group, and the MMSE, PM scale, and the RM scale score were not statistically significant. The multivariate Logistic regression analysis showed that three negative breast cancer (OR=3.763, P=0.005), Age (OR=1.097, P0.000 1) is a risk factor for cognitive impairment in breast cancer patients. Conclusion breast cancer chemotherapy patients have different degrees of cognitive impairment, compared with non three negative breast cancer patients, three negative breast cancer patients with severe cognitive impairment, the difference is mainly in young patients, while three negative breast cancer and age are both. Risk factors for CICI in breast cancer.

【作者单位】：安徽医科大学第一附属医院肿瘤内科;安徽医科大学第二附属医院肿瘤中心;
【基金】：国家自然科学基金(编号:81372487) 安徽医科大学校科研基金资助项目(编号:2015xkj101)
【分类号】：R737.9

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