肿瘤糖代谢紊乱的研究进展和探索

发布时间：2018-04-22 09:37

本文选题：肿瘤代谢 + 瓦伯格效应　；参考：《中山大学学报(医学科学版)》2017年02期

【摘要】：异于正常细胞的代谢紊乱是肿瘤细胞的典型特征之一,其中最具有代表性的是葡萄糖的代谢紊乱。正常细胞在有氧的环境中主要依靠线粒体的氧化磷酸化代谢葡萄糖并产生能量,而在低氧环境下会迫使糖代谢转向糖酵解通路。肿瘤细胞出于其恶性增殖的需要,在各种环境中都呈现出高速的糖酵解现象,这被称为瓦伯格效应。诱发瓦伯格效应有多种机制,包括肿瘤微环境的影响,促癌信号转导通路的激活以及代谢酶的表达紊乱等。此外,我们的近期研究表明,抑制肿瘤细胞中糖酵解的相反过程—糖异生通路也可进一步促进肿瘤的瓦伯格效应与恶性进展。
[Abstract]:Metabolic disorder is one of the typical characteristics of tumor cells, and glucose metabolism disorder is the most representative. Normal cells mainly rely on the oxidative phosphorylation of mitochondria to metabolize glucose and produce energy in aerobic environment, while in hypoxic environment, glucose metabolism is forced to switch to glycolytic pathway. Due to the need of malignant proliferation, tumor cells exhibit high-speed glycolysis in various environments, which is called the Warburg effect. There are many mechanisms to induce Wahlberg effect, including the effect of tumor microenvironment, the activation of signal transduction pathway and the disturbance of metabolic enzyme expression. In addition, our recent studies have shown that inhibiting the reverse process of glycolysis in tumor cells, the glycosylated allogeneic pathway, may further promote the Wahlberg effect and the malignant progression of tumors.
【作者单位】：中山大学中山医学院生化教研室;中山大学中山医学院心血管研究群体;
【基金】：国家自然科学基金优秀青年科学基金(81622034);国家自然科学基金面上项目(81572508)
【分类号】：R730.2

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