肿瘤干细胞微环境与靶向干预策略

发布时间：2018-04-22 17:02

本文选题：肿瘤干细胞 + 自我更新调控　；参考：《生物化学与生物物理进展》2017年08期

【摘要】：肿瘤干细胞具有自我更新和可塑性的潜能,能够维持肿瘤生长和异质性的能力.肿瘤干细胞是肿瘤产生、转移、耐药和复发的根源,肿瘤干细胞学说逐渐被肿瘤研究者所接受,因此,对肿瘤干细胞的深入理解有重大的科学和临床意义.肿瘤干细胞的微环境是肿瘤微环境的组成部分,包括细胞-细胞接触、分泌型因子等.肿瘤非干细胞和肿瘤干细胞本身都可以作为肿瘤干细胞的微环境.肿瘤干细胞的微环境可以维持肿瘤干细胞的可塑性,保护肿瘤干细胞免受免疫系统攻击,也可以促进其转移.肿瘤干细胞对其微环境的塑造、肿瘤干细胞的微环境对肿瘤干细胞自我更新的影响,以及针对肿瘤干细胞微环境的靶向干预等问题,已成为肿瘤干细胞研究的前沿问题.本文就肿瘤干细胞的发现、自我更新维持机制、肿瘤干细胞的微环境,及其肿瘤干细胞及微环境的干预策略等研究进展进行了综述.
[Abstract]:Tumor stem cells have the potential of self-renewal and plasticity and can maintain tumor growth and heterogeneity. Tumor stem cells are the root of tumor generation, metastasis, drug resistance and recurrence. The theory of tumor stem cells is gradually accepted by cancer researchers. Therefore, it is of great scientific and clinical significance to understand tumor stem cells deeply. The microenvironment of tumor stem cells is an integral part of tumor microenvironment, including cell-cell contact, secretory factors and so on. Tumor non-stem cells and tumor stem cells themselves can be used as microenvironment of tumor stem cells. The microenvironment of tumor stem cells can maintain the plasticity of tumor stem cells, protect tumor stem cells from attack by the immune system, and promote their metastasis. The modeling of tumor stem cells to its microenvironment, the effect of tumor stem cell microenvironment on the self-renewal of tumor stem cells, and the targeted intervention against tumor stem cell microenvironment have become the frontier of tumor stem cell research. In this review, the discovery of tumor stem cells, the mechanism of self-renewal, the microenvironment of tumor stem cells, and the intervention strategies of tumor stem cells and microenvironment were reviewed.
【作者单位】：中国科学院生物物理研究所;
【基金】：国家自然科学基金资助项目(81330047)~~
【分类号】：R730

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