CD56 CgA Syn在92例原发食管小细胞癌中的表达及临床意义和预后分析

发布时间：2018-04-23 12:31

本文选题：原发食管小细胞癌 + 嗜铬粒蛋白A　；参考：《中国肿瘤临床》2017年05期

【摘要】：目的:探讨神经内分泌标志物突触素(synaptophysin,Syn)、神经细胞黏附分子56(neuronal cell adhesion molecules 56,CD56)、嗜铬粒蛋白A(chromogranin A,CgA)在92例食管小细胞癌(primary esophageal small cell carcinoma,PESC)中的表达,并分析其表达与患者临床病理特征和预后间关系。方法:采用免疫组织化学法(immunohistochemisty,IHC)检测PESC中CD56、CgA、Syn分子表达;logistic回归分析其与患者临床病理特征关系;Kaplan-Meier法、Cox多因素回归法进行单因素和多因素生存分析;Log-rank法比较各组间生存曲线差异。结果:食管下段癌组织中CgA阳性表达率高于食管中、上段(72.2%vs.41.1%vs.10.0%),且差异具有统计学意义(P=0.001)。CD56、CgA、Syn表达与患者性别(P=0.262,0.998,0.931)、年龄(P=0.250,0.998,0.703)、肿瘤浸润深度(P=0.253,0.997,0.061)、淋巴结有无转移(P=0.767,0.998,0.613)无关;N1、N0的PESC生存期差异无统计学意义(P=0.563);PESC混合鳞癌(HR=2.58;95%CI:1.11~5.98)及CgA阳性表达PESC(HR=1.87;95%CI:1.02~3.43)预后优于单纯PESC及CgA阴性表达患者。结论:CgA表达与PESC肿瘤部位有关;淋巴结有无转移不影响PESC患者预后;组织学类型及CgA表达是PESC患者预后独立影响因素。
[Abstract]:Objective: To investigate the expression of neuroendocrine marker synaptophysin (Syn), neuronal cell adhesion molecules 56 (CD56), chromaffin A (chromogranin A, CgA) in 92 cases of small cell carcinoma of the esophagus, and to analyze its expression and clinicopathological characteristics. The relationship between the sign and the prognosis. Methods: immunohistochemisty (IHC) was used to detect the expression of CD56, CgA, Syn molecules in PESC; logistic regression analysis was used to analyze the relationship with the clinicopathological features of the patients; Kaplan-Meier, Cox multifactor regression method was used to analyze the survival analysis of single factor and multifactorin; Log-rank method was used to compare the difference of survival curves between each group. Results: the positive rate of CgA in the lower esophageal carcinoma tissues was higher than that in the esophagus, the upper segment (72.2%vs.41.1%vs.10.0%), and the difference was statistically significant (P=0.001).CD56, CgA, Syn expression and sex (P=0.262,0.998,0.931), age (P=0.250,0.998,0.703), tumor infiltration depth (P=0.253,0.997,0.061), and lymph node metastasis (P=0.767,0.998,0.613). There was no significant difference in the survival time of N1 and N0 (P=0.563), and the prognosis of PESC mixed squamous cell carcinoma (HR=2.58; 95%CI:1.11~5.98) and CgA positive expression PESC (HR=1.87; 95%CI:1.02~3.43) was better than that of the simple PESC and negative expression patients. Type CgA expression is an independent prognostic factor in PESC patients.

【作者单位】：南阳医学高等专科学校基础医学部;郑州大学第一临床学院河南省食管癌重点开放实验室;南阳医学高等专科学校第一附属医院;南阳医学高等专科学校第二附属医院;
【基金】：国家自然科学基金委员会-广东省联合重大项目(编号:U1301227) 河南省教育厅高等学校重点科研项目(编号:15B320006)资助~~
【分类号】：R735.1

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