联合检测术前与术后CEA CA19-9 CA72-4对不同分期胃癌根治术后复发的预测价值

发布时间：2018-04-23 15:31

  本文选题：胃癌 + 肿瘤标志物　； 参考：《中国肿瘤临床》2017年07期

【摘要】：目的:探讨联合检测术前、术后CEA、CA19-9、CA72-4等肿瘤标志物对不同分期胃癌根治术后复发的预测价值。方法:回顾性分析北京大学肿瘤医院2002年1月至2007年3月收治的564例胃癌患者的临床资料及血清肿瘤标志物情况。所有患者均未行新辅助治疗,术前、术后均联合检测CEA、CA19-9、CA72-4等肿瘤标志物。分析CEA、CA19-9、CA72-4等肿瘤标志物与胃癌复发的关系。结果:在Ⅰ、Ⅱ期胃癌患者中,CEA、CA19-9、CA72-4术前阳性的患者术后复发率分别为50.0%、24.1%、22.6%,而术后阳性的患者复发率分别为42.9%、21.7%、14.3%。在Ⅲ期胃癌患者中,CEA、CA19-9、CA72-4术前阳性的患者术后复发率分别为50.0%、55.2%、47.6%,而术后阳性的患者术后复发率分别为75.0%、66.7%、66.7%。多因素分析表明术前CEA增高是Ⅰ、Ⅱ期胃癌复发的独立影响因素,术后CA72-4增高是Ⅲ期胃癌复发的独立影响因素。结论:对于Ⅰ、Ⅱ期胃癌,术前CEA水平是预测复发较好的因子;对于Ⅲ期胃癌,术后CA72-4水平的预测性较好。
[Abstract]:Objective: to evaluate the value of combined detection of preoperative and postoperative tumor markers such as CA19-9 and CA72-4 in predicting the recurrence of gastric cancer after radical resection with different stages. Methods: the clinical data and serum tumor markers of 564 patients with gastric cancer admitted to Peking University Cancer Hospital from January 2002 to March 2007 were retrospectively analyzed. All the patients were not treated with neoadjuvant therapy. The tumor markers such as CA19-9 and CA72-4 were detected before and after operation. To analyze the relationship between tumor markers such as CA19-9, CA72-4 and recurrence of gastric cancer. Results: among the patients with stage 鈪，

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