循环miR-21对胰腺癌诊断价值的Meta分析

发布时间：2018-04-25 00:07

本文选题：胰腺肿瘤/诊断 + 微RNAs　；参考：《中国普通外科杂志》2017年09期

【摘要】：目的:通过Meta分析系统评价血液中miR-21对胰腺癌的诊断价值。方法:检索多个国内外数据库,收集2017年5月以前公开发表的关于miR-21用于胰腺癌诊断的研究数据,按照纳入标准筛选文献、提取资料和质量评价,然后采用Metadisc 1.4和Stata 14.0软件对纳入研究进行Meta分析。结果:共纳入8篇文献,累计261例胰腺癌患者和242例对照。Meta分析结果显示,循环miR-21诊断胰腺癌的合并敏感度为0.76(95%CI=0.71~0.81),合并特异度为0.76(95%CI=0.70~0.81),合并阳性似然比为3.17(95%CI=2.24~4.47),合并阴性似然比为0.26(95%CI=0.15~0.45),合并诊断比值比为13.17(95%CI=6.78~25.58)。综合受试者工作特征曲线下面积(AUC)为0.8518。亚组分析显示,血清和血浆亚组的AUC均为0.8513;健康人群对照亚组的诊断准确性优于健康人群+胰腺良性疾患对照亚组(AUC:0.876 vs.0.72,P0.05)。诊断性试验Deek漏斗图显示不存在发表偏倚,敏感性分析显示Meta分析结果并未过分依赖于某个研究,结论稳定。结论:循环miR-21用于胰腺癌诊断具有一定的价值。
[Abstract]:Objective: to evaluate the diagnostic value of blood miR-21 in pancreatic cancer by Meta analysis system. Methods: a number of domestic and foreign databases were searched, and the data on miR-21 used in pancreatic cancer diagnosis were collected and published before May 2017. The literature was screened according to the inclusion criteria, and the data were extracted and evaluated. Metadisc 1.4 and Stata 14.0 software were used to analyze the inclusion study by Meta. Results: a total of 8 articles were included. A total of 261 cases of pancreatic cancer and 242 cases of control group were analyzed by Meta-analysis. The combined sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic ratio of circulating miR-21 for diagnosis of pancreatic cancer were 0.7695, 0.76, 0.700.81, 3.17, 2.24, 4.47, 0.2695, 0.150.45 and 13.1795, 6.78 and 25.58, respectively. The area under the operating characteristic curve was 0. 8518. The results of subgroup analysis showed that the AUC of serum and plasma subgroup was 0.8513, and the diagnostic accuracy of healthy population control subgroup was better than that of healthy control group with benign pancreatic diseases (AUC: 0.876 vs.0.72P 0.05). In diagnostic test, Deek funnel graph showed no publication bias, sensitivity analysis showed that the results of Meta analysis were not overly dependent on a certain study, and the conclusion was stable. Conclusion: circulating miR-21 is valuable in the diagnosis of pancreatic cancer.
【作者单位】：中国人民解放军第一七五医院/厦门大学附属东南医院普通外科;中国人民解放军第一七五医院/厦门大学附属东南医院医务处;
【基金】：中国人民解放军第一七五医院青年苗圃基金资助项目(16Y006)
【分类号】：R735.9

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