不同部位结直肠癌临床特点及MLH1、MSH2、MSH6、PMS2表达的研究

发布时间：2018-04-25 00:30

本文选题：结直肠癌 + 发病部位　；参考：《新疆医科大学》2017年硕士论文

【摘要】：目的:比较不同发病部位的结直肠癌,其在临床特点及MLH1、MSH2、MSH6、PMS2蛋白表达上的差异,为临床治疗及预后判断提供参考。方法:回顾性分析了我院及外院于2010年01月01日至2016年12月31日期间诊治的173例结直肠癌患者,均经手术或肠镜检查治疗,有完整的资料。根据患者发病部位的不同将患者分为三组:右半结肠癌组、左半结肠癌组和直肠癌组。记录患者的年龄、性别、大体类型、分化程度、病理分期、MLH1、MSH2、MSH6、PMS2(错配修复基因相关蛋白)等指标。比较上述因素之间是否存在差异。结果:1.本组资料173例患者,三组不同发病部位的结直肠癌患者在年龄上无明显差异(P0.05);三组结直肠癌患者在性别分布上无明显差异(P0.05);右半结肠组、左半结肠组和直肠组三种分化程度的比较三者之间差异无统计学意义(P0.05);2.本组资料显示三组资料在肿瘤的大体类型上相比存在差异,(左半结肠癌、直肠癌)溃疡型所占比例较(右半结肠)所占比例高,差异有统计学意义(P0.05);本组资料显示不同发病部位的结直肠癌在病理分期上差异无统计学意义(P0.05);3.三组资料在MLH1、MSH6、PMS2蛋白表达与肿瘤的发病部位显著相关(P0.05);MSH2蛋白在不同发病部位间的结直肠癌表达差异无统计学意义(P0.05)。结论:1.三组不同发病部位的结直肠癌患者在年龄及性别分布上无明显差异。2.三组资料间比较分化程度无差异,左半结肠、直肠癌溃疡型较右半结肠癌高。3.右半结肠癌MLH1、MSH6和PMS2蛋白表达阴性率比左半结肠癌和直肠癌组高,错配修复基因表达缺失多发生于右半结肠癌。
[Abstract]:Objective: to compare the clinical features and the expression of MLH1MSH2MSH6PMS2 protein in colorectal cancer with different sites, and to provide reference for clinical treatment and prognosis. Methods: 173 cases of colorectal cancer treated in our hospital and our hospital from January 01, 2010 to December 31, 2016 were analyzed retrospectively. Patients were divided into three groups: right colon cancer group, left colon cancer group and rectal cancer group. The age, sex, gross type, differentiation degree and pathological stage of the patients were recorded, such as MLH1 / MSH2 / MSH6 / PMS2 (mismatch repair gene associated protein). Compare the differences between the above factors. The result is 1: 1. There was no significant difference in age between three groups of patients with colorectal cancer at different sites, there was no significant difference in sex distribution among three groups of patients with colorectal cancer (P 0.05), and in the right half colon group, there was no significant difference in sex distribution among the three groups. There was no significant difference in the degree of differentiation between the left colon group and the rectum group. The data showed that the proportion of ulcerative type in the three groups was higher than that in the right colon. The difference was statistically significant (P 0.05) and there was no significant difference in pathological stage of colorectal cancer in different sites. The expression of PMS2 protein in MLH1 and MSH6 was significantly correlated with the location of tumor. There was no significant difference in the expression of P0.05 / MSH2 protein between different sites of colorectal cancer. Conclusion 1. There was no significant difference in age and sex distribution among three groups of colorectal cancer patients with different sites. There was no difference in the degree of differentiation between the three groups. The ulcerative type of the left colon and rectal cancer was higher than that of the right colon cancer. The negative rate of MLH1mH6 and PMS2 protein expression in right colon cancer was higher than that in left colon cancer and rectal cancer. The mismatch repair gene deletion occurred in right colon cancer.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.34

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