IDH1在NSCLC中的表达及与常用肿瘤标志物联合检测的临床意义

发布时间：2018-04-25 08:01

本文选题：异柠檬酸脱氢酶1 + 非小细胞肺癌　；参考：《新疆医科大学》2015年硕士论文

【摘要】：目的：探讨检测异柠檬酸脱氢酶1(Isocitrate dehydrogenase 1, IDH1)、癌胚抗原(CEA)、糖类抗原125(CA125)及细胞角蛋白19片段(Cyfra21-1)在非小细胞肺癌(Non-small lung cell cancer,NSCLC)中的诊断及疗效评价的临床意义。方法：新疆医科大学附属肿瘤医院143例临床确诊的NSCLC患者和100例健康人群中IDH1阳性率的比较；NSCLC患者化疗前IDH1、CEA、CA125、Cyfra21-1的敏感度及准确度；NSCLC患者经过2个周期的化疗,监测肺腺癌和肺鳞癌2组不同病理类型化疗前后IDH1与其他标志物CEA、CA125、Cyfra21-1水平的变化,结合其化疗前后变化进行分析并评价疗效。结果：单一的肿瘤标志物检测的敏感度及准确度不及联合检测,差异具有统计学意义。肺腺癌患者IDH1、CEA、CA125在部分缓解(PR)患者中明显降低,IDH1、CEA在病变进展(PD)患者中明显升高,差异均有统计学意义；CA125在病变稳定(SD)及PD患者中差异无明显变化。肺鳞癌患者IDH1、Cyfra21-1在PR患者中明显降低,IDH1在PD患者中明显升高,差异具有统计学意义,在SD患者中无明显变化。结论：肿瘤标志物联合检测比单项检测更有意义；化疗前后IDH1、CEA、CA125、Cyfra21-1血清水平的变化与治疗效果密切相关；血清IDH1水平增高与NSCLC患者的年龄、性别、吸烟史、临床分期、肿瘤分化程度及病理类型有关。
[Abstract]:Objective: to investigate the clinical significance of detection of isocitrate dehydrogenase (1(Isocitrate dehydrogenase 1, IDH1), carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125) and cytokeratin 19 fragment (Cyfra21-1) in non-small lung cell cancer (NSCLC) of non-small lung lung cancer (NSCLC). Methods: the positive rate of IDH1 was compared in 143 patients with NSCLC and 100 healthy controls in Cancer Hospital affiliated to Xinjiang Medical University. The sensitivity and accuracy of IDH1-CEACA125 Cyfra21-1 in NSCLC patients underwent two cycles of chemotherapy. The changes of IDH1 and other markers CEACA125hCyfra21-1 in lung adenocarcinoma and lung squamous cell carcinoma before and after chemotherapy were monitored. The changes before and after chemotherapy were analyzed and the curative effect was evaluated. Results: the sensitivity and accuracy of single tumor marker detection were lower than that of combined detection, and the difference was statistically significant. In patients with lung adenocarcinoma, the level of CEACA125 was significantly lower in patients with partial remission of PRA than that in patients with PDD. The difference was statistically significant. There was no significant difference between the two groups in stable SDV and PD. In patients with lung squamous cell carcinoma, IDH1Cyfra21-1 was significantly decreased in PR patients and increased significantly in PD patients, the difference was statistically significant, but there was no significant change in SD patients. Conclusion: the combined detection of tumor markers is more significant than the single detection, the changes of serum level of IDH1C CEA CA125 and Cyfra21-1 before and after chemotherapy are closely related to the therapeutic effect, and the increase of serum IDH1 level is associated with the age, sex, smoking history, clinical stage of NSCLC patients. The degree of tumor differentiation is related to the pathological type.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R734.2

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