伴有钙化的乳腺浸润性导管癌的病理特征及预后分析

发布时间：2018-04-25 17:28

本文选题：乳腺肿瘤 + 钙化　；参考：《新疆医科大学》2017年硕士论文

【摘要】：目的:探讨乳腺浸润性导管癌中钙化的临床病理特征及预后的影响因素。方法:回顾性收集2012年6月-2013年6月在新疆肿瘤医院乳腺外科收治的初治可行乳腺癌改良根治术/保乳根治术/单纯切除术的307例女性乳腺癌患者的临床病理资料及随访资料,根据乳腺X线图像特征分为钙化组与非钙化组,采用χ2检验分析其临床病理特征之间的差异,逐步Logistic回归分析影响钙化存在的相关因素,运用Kaplan-Meier生存分析方法分析钙化的表达与患者生存之间的关系。结果:(1)钙化组在病理类型,淋巴结转移,人表皮生长因子受体2(Her-2)过表达,组织学分级,临床分期、分子分型、Ki67与非钙化组比较差异有统计学意义(χ2=21.551、8.480、10.558、6.283、9.682、16.380、3.947,P=0.000、0.037、0.005、0.043、0.021、0.001、0.047)。(2)钙化是淋巴结转移及Her-2过表达的相关风险因素。钙化组淋巴结转移的风险是非钙化组的1.736倍;钙化组Her-2过表达的风险是非钙化组的2.297倍(P=0.022、0.007,OR=1.736、2.297,95%CI:1.084-2.779、1.260-4.187)。(3)钙化组和非钙化组3年无病生存率分别是84.42%和96.15%。对乳腺浸润性导管癌的预后行COX多因素分析提示钙化和淋巴结状态(淋巴结阳性4-9个和9个)是影响乳腺浸润性导管癌无病生存时间的独立预后危险因素(P=0.008、0.000(0.021、0.000),95%Cl:1.380-8.510、1.231-12.144和2.570-20.492)。结论:钙化是乳腺浸润性导管癌预后较差的影响因子。
[Abstract]:Objective: to investigate the clinicopathological features and prognostic factors of calcification in invasive ductal carcinoma of breast. Methods: the clinicopathological data and follow-up data of 307 female breast cancer patients who were treated in breast surgery department of Xinjiang tumor Hospital from June 2012 to June 2013 were retrospectively collected. According to the characteristics of mammogram, the patients were divided into calcified group and non-calcified group. 蠂 2 test was used to analyze the difference between the clinicopathological features and stepwise Logistic regression analysis was used to analyze the related factors affecting the existence of calcification. Kaplan-Meier survival analysis was used to analyze the relationship between calcification expression and patient survival. Results in the calcification group, pathological type, lymph node metastasis, expression of human epidermal growth factor receptor (EGF receptor 2) Her-2), histological grade, and clinical stage were observed. There was significant difference between the molecular typing group and non-calcified group (蠂 ~ 2 + 21.551 ~ 8.480 ~ 10.558 ~ 6.283C ~ (9.682) ~ (16.380) ~ 3.947) calcification was a risk factor of lymph node metastasis and overexpression of Her-2. It was a risk factor of lymph node metastasis and overexpression of Her-2 by 0.037 ~ 0.005 ~ 0. 043 ~ 0. 021 ~ 0. 041 ~ 0. 047. 2) there was a significant difference between the two groups (蠂 ~ (2) ~ (21) 551) and non-calcification (蠂 ~ (2). The risk of lymph node metastasis in the calcified group was 1.736 times higher than that in the non-calcified group, and the risk of Her-2 overexpression in the calcified group was 2.297 times higher than that in the non-calcified group. The 3-year disease-free survival rate was 84.42% in the calcified group and 96.15.1% in the non-calcified group. COX multivariate analysis showed that calcification and lymph node status (positive lymph nodes 4-9 and 9 lymph nodes) were independent prognostic risk factors for the survival time of invasive ductal carcinoma of breast without disease. Conclusion: calcification is a poor prognostic factor in invasive ductal carcinoma of the breast.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.9

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