宫颈浆液性腺癌5例临床及病理资料分析

发布时间：2018-04-25 18:15

本文选题：宫颈浆液性腺癌 + 临床　；参考：《大连医科大学》2017年硕士论文

【摘要】：目的:回顾性分析宫颈浆液性腺癌的临床及病理资料,对其临床特点、病理特征、诊断、治疗及预后进行分析研究。方法:收集大连医科大学附属第一医院及大连市妇产医院1990年1月-2017年1月经病理确诊的5例宫颈浆液性腺癌临床及病理资料进行回顾性分析。结果:(1)5例患者中位年龄44岁(41-64岁);(2)临床表现:阴道不规则流血或接触性出血(3/5),下腹不适或腰痛1例(1/5),无异常表现1例(1/5);(3)盆腔检查:宫颈菜花样肿物或赘生物(3/5)、宫颈糜烂或糜烂样增生(2/5)。(4)根据2009年FIGO临床分期:3例Ib1期,2例Ib2期。(5)治疗:5例均接受手术治疗,3例行根治性子宫切除术及双附件切除术及盆腔淋巴结清扫术,1例行全子宫及双附件切除术及盆腔淋巴结清扫术,1例患者行全子宫切除术;2例行新辅助或术后化疗,1例术后辅助放疗。(6)浸润转移:5例均为Ib期,排除1例未行淋巴结清扫,宫颈深间质浸润者(宫颈1/2)占100%,淋巴脉管间隙浸润者(lymph-vascular space invasion,LVSI)占 100%,盆腔淋巴结移者占 100%,其中2例行腹主动脉旁淋巴结清扫,均伴有腹主动脉旁淋巴结转移。(7)随访:3例获得随访资料,2例失访,随访时间5-31个月,1例2年后盆腔复发,1例术后9个月因"广泛转移"死亡,1例无瘤生存5个月。结论:宫颈浆液性腺癌是一类具有高侵袭性的宫颈腺癌亚型,其临床表现与宫颈癌相似,淋巴结转移可能是其最早的转移途径。
[Abstract]:Objective: to retrospectively analyze the clinical and pathological data of cervical serous adenocarcinoma and analyze its clinical features, pathological features, diagnosis, treatment and prognosis. Methods: the clinical and pathological data of 5 cases of cervical serous adenocarcinoma diagnosed from January 1990 to January 2017 in the first affiliated Hospital of Dalian Medical University and Dalian Maternity Hospital were retrospectively analyzed. Results the median age of 5 patients was 44 years old and 41-64 years old.) Clinical manifestations: irregular vaginal bleeding or contact hemorrhage (3 / 5), lower abdomen discomfort or low back pain (1 / 5), no abnormal findings (1 / 1 / 5) pelvic examination: cervix jugular neoplasms or neoplasms 3 / 5, uterus. Cervical erosion or erosive Hyperplasia 2 / 5. 4) according to the 2009 FIGO clinical stage: 3 cases with Ib1 stage 2 cases with Ib2 stage 5 cases were treated with surgery. 3 cases underwent radical hysterectomy, 3 cases underwent double appendage hysterectomy and 1 case underwent pelvic lymph node dissection. Hysterectomy, double appendage resection and pelvic lymph node dissection were performed in 1 patient with total hysterectomy, 2 cases with neoadjuvant or postoperative chemotherapy and 1 case with postoperative adjuvant radiotherapy. One case was excluded from lymph node dissection, 100 cases had deep interstitial invasion (1 / 2 of cervix), 100 cases had lymph-vascular space invasionus (LVSI), and 100 cases had pelvic lymph node metastasis. Two cases were followed up for 5 to 31 months, 1 case with pelvic recurrence 2 months after operation, 1 case died of "extensive metastasis" 9 months after operation, 1 case survived 5 months without aneurysm. Conclusion: cervical serous adenocarcinoma is a highly invasive subtype of cervical adenocarcinoma, and its clinical manifestation is similar to that of cervical carcinoma. Lymph node metastasis may be the earliest way of metastasis.
【学位授予单位】：大连医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.33

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