幽门螺杆菌感染与胰腺癌关系的Meta分析

发布时间：2018-04-26 00:26

本文选题：幽门螺杆菌 + 胰腺癌　；参考：《暨南大学》2015年硕士论文

【摘要】：目的:探讨幽门螺杆菌(Helicobacter pylori,H.pylori)感染与胰腺癌的关系。方法:检索相关文献,对符合纳入标准的文献进行资料提取,用Revman5.3软件进行meta分析,估计合并效应量OR值及对应的95%可信区间(95%CI),再绘制漏斗图评价发表性偏倚。结果:共纳入8篇文献,病例组和对照组共3133例。H.pylori感染与胰腺癌关系的合并OR值为1.27,95%CI:1.04-1.56,I2=24%。按照研究对象人种不同,分为东、西方两个亚组,西方人群(OR=1.14,95%CI:0.91-1.42,I2=0%),表明H.pylori感染与胰腺癌没有关系,但东方人群(OR=2.06,95%CI:1.29-3.29,I2=0%),表明H.pylori感染与胰腺癌有关系,且H.pylori感染是胰腺癌的危险因素,倒漏斗图示基本对称。有6篇文献检测Cag A+,其合并OR值为1.32,95%CI:0.83-2.10,I2=72%,亚组分析示西方人群(OR=0.92,95%CI:0.73-1.16,I2=0%),表明Cag A+与胰腺癌没有关系,但东方人群(OR=4.29,95%CI:2.14-8.60,I2=0%),表明Cag A+与胰腺癌有关系,且Cag A+可增加患胰腺癌的风险。结论:东方人群H.pylori感染和Cag A+可增加患胰腺癌的风险,西方人群H.pylori感染和Cag A+与胰腺癌没有关系。
[Abstract]:Objective: to investigate the relationship between Helicobacter pylori H.pylori infection and pancreatic cancer. Methods: the relevant literature was retrieved, and the data of the literature that met the inclusion criteria were extracted. The meta analysis was carried out with Revman5.3 software. The OR value of the combined effect and the 95% confidence interval (95% CI) were estimated, and then the funnel graph was drawn to evaluate the published bias. Results: a total of 8 articles were included. The OR value of 3133 cases of H.pylori infection and pancreatic cancer was 1.2795 CI: 1.04-1.56I224.4. According to the different race of the subjects, they were divided into two subgroups of east and west, and the Western population was 1.1495, and the H.pylori infection had no relationship with pancreatic cancer, but the oriental population had no relationship with pancreatic cancer, which indicated that H.pylori infection was associated with pancreatic cancer, and H.pylori infection was the risk factor of pancreatic cancer. The inverted funnel is basically symmetrical. Six papers examined Cag A, with a OR value of 1.32 卤95CI0.83-2.10 and I2720.The subgroup analysis showed that Cag A had no relationship with pancreatic cancer, but Cag A had no relationship with pancreatic cancer, indicating that Cag A was associated with pancreatic cancer, and Cag A could increase the risk of pancreatic cancer. Conclusion: H.pylori infection and Cag A in oriental population can increase the risk of pancreatic cancer, but H.pylori infection and Cag A in western population are not associated with pancreatic cancer.
【学位授予单位】：暨南大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R735.9

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