确诊年龄与甲状腺微小乳头状癌颈部中央区淋巴结转移相关性研究

发布时间：2018-04-27 01:32

  本文选题：甲状腺微小乳头状癌 + 中央区淋巴结转移　； 参考：《中国实用外科杂志》2017年09期

【摘要】：目的探讨甲状腺微小乳头状癌(PTMC)临床病理学特征及中央区淋巴结转移(CLNM)危险因素;尤其探讨不同年龄截点下,确诊年龄与CLNM相关性,阐述确诊年龄实际意义。方法回顾性分析新疆医科大学附属肿瘤医院2010年1月至2016年3月初治的1988例PTMC病人临床病理学特征,通过χ2检验、ROC曲线及多因素统计分析,探讨CLNM危险因素。又将25~70岁年龄区间中每5岁及30~60岁年龄区间中每岁为年龄截点,分别探讨不同年龄截点下,确诊年龄与PTMC中央区淋巴结转移相关性。结果 CLNM发生率为34.9%,且其随确诊年龄增加而明显下降。除70岁截点外,25~70岁年龄区间中每5岁及30~60岁年龄区间中每岁为截点差异均有统计学意义(P0.05),即上述确诊年龄截点均可提示确诊年龄是CLNM独立危险因素。多因素分析显示,男性、肿瘤数目≥3枚、肿瘤直径5 mm、单灶位于下极、包膜浸润是影响CLNM发生的独立危险因素(P0.05)。结论确诊年龄是PTMC中央区淋巴结转移独立危险因素,但其仅反映CLNM风险变化趋势,无确定截点;将年龄看成连续型变量,在相关研究结果阐述中更加合理。其次,当PTMC存在以下情况,如男性、肿瘤数目≥3枚、肿瘤直径5 mm、单灶位于下极、包膜浸润,应警惕CLNM可能。
[Abstract]:Objective to investigate the clinicopathological features and risk factors of central lymph node metastasis (CLNM) in thyroid micropapillary carcinoma, especially to explore the correlation between the age of diagnosis and CLNM at different age points, and to elucidate the practical significance of the age of diagnosis. Methods the clinicopathological characteristics of 1988 patients with PTMC treated in Cancer Hospital affiliated to Xinjiang Medical University from January 2010 to early March 2016 were analyzed retrospectively. The risk factors of CLNM were analyzed by 蠂 2 test and multivariate statistical analysis. At the same time, every 5 years and 30 ~ 60 years old of 2570 years old were regarded as the age cutoff points, and the correlation between the diagnosis age and the lymph node metastasis in the central area of PTMC was studied respectively under different age cutoff points. Results the incidence of CLNM was 34.9, and it decreased with the age of diagnosis. There was significant difference between every 5 years old and 30 ~ 60 years old in every 5 years old and 30 ~ 60 years old except 70 years old cut point, which indicated that the diagnosis age was an independent risk factor of CLNM. Multivariate analysis showed that in male, the number of tumors was more than 3, the diameter of tumor was 5 mm, the single focus was located at the lower pole, and the capsule invasion was an independent risk factor for the occurrence of CLNM (P 0.05). Conclusion the age of diagnosis is an independent risk factor for lymph node metastasis in the central region of PTMC, but it only reflects the trend of CLNM risk change and has no definite cut-off point. The age is regarded as a continuous variable, which is more reasonable in the elaboration of relevant research results. Secondly, when PTMC exists the following conditions, such as male, the number of tumor 鈮，

本文编号：1808607