射频消融术与立体定向放射治疗原发性小肝癌的临床效果比较

发布时间：2018-04-27 02:17

  本文选题：肝癌 + 射频消融术　； 参考：《肿瘤防治研究》2017年12期

【摘要】：目的比较射频消融术(radiofrequency ablation,RFA)和立体定向放射治疗(stereotactic body radiotherapy,SBRT)对原发性小肝癌患者的临床疗效及安全性。方法回顾性分析2013年6月至2015年3月河南省肿瘤医院收治的肝癌患者86例,RFA组49例、SBRT组37例。比较两组近期疗效、不良反应发生情况以及随访2年总生存率和肿瘤病灶局部控制率。结果两组患者基线资料差异无统计学意义。RFA组患者近期治疗有效率为81.9%,疾病控制率达到95.9%;SBRT组近期有效率为83.8%,疾病控制率达到91.9%,两组差异无统计学意义。两组治疗后均未出现严重并发症。RFA组治疗后1年和2年总生存率为95.9%和85.7%,SBRT组分别为91.9%和83.8%,两组差异无统计学意义。结论 RFA介入治疗与SBRT治疗对肿瘤直径≤5 cm的单发肝癌患者具有较好的近期和远期疗效,对于不适合手术切除的肝癌患者,立体定向放疗可以作为射频消融术治疗的一种替代手段。
[Abstract]:Objective to compare the clinical efficacy and safety of radiofrequency ablation (RFA) and stereotactic body radiotherapySBRT (stereotactic body radiotherapySBRT) in patients with small hepatocellular carcinoma (HCC). Methods from June 2013 to March 2015, 86 patients with liver cancer treated in Henan Cancer Hospital were analyzed retrospectively. There were 49 patients in RFA group and 37 patients in SBRT group. The short-term curative effect, adverse reaction, 2-year survival rate and local control rate of tumor were compared between the two groups. Results there was no significant difference in baseline data between the two groups. The effective rate of short-term treatment was 81.9 in RFA group, 83.8 in SBRT group and 91.9 in SBRT group. There was no significant difference between the two groups. There were no serious complications in both groups. The 1 and 2 year overall survival rates of RFA group were 91.9% and 83.8%, respectively. There was no significant difference between the two groups. Conclusion RFA interventional therapy and SBRT therapy have good short-term and long-term results in patients with single HCC with tumor diameter 鈮，

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