宫颈病变中HPV基因型分布的比较

发布时间：2018-04-27 04:20

本文选题：人乳头瘤病毒 + 宫颈上皮内瘤变　；参考：《医学研究生学报》2017年12期

【摘要】：目的宫颈癌发病主要由高危型人乳头瘤病毒(HPV)所致。文中研究宫颈病变中HPV基因型的分布。方法回顾性分析2015年1月至2015年12月于江苏大学附属医院行宫颈组织学检查,且术前6个月内行HPV基因分型检测的798例宫颈病变患者HPV感染情况,探讨HPV基因型与宫颈病变的相关性。结果进行宫颈组织学检查的798例患者中,759例存在HPV感染,总阳性率达95.11%;其中238例为混合感染,混合感染率为29.82%。本组最常见HPV单一感染型别前5位分别为16、52、58、53、51。不同程度宫颈病变中主要以HPV单一型别感染为主(68.64%);多重型别感染中以双重感染居多,宫颈癌患者尤甚(85.71%)。结论不同HPV型别所致宫颈病变级别不同。对HPV进行分型检测,并对高危型HPV感染患者进行宫颈活检,将有助于早期发现宫颈病变。
[Abstract]:Objective Cervical cancer is mainly caused by high-risk human papillomavirus (HPV). The distribution of HPV genotypes in cervical lesions was studied. Methods from January 2015 to December 2015, 798 patients with cervical lesions who underwent cervical histological examination from January 2015 to December 2015 and HPV genotyping within 6 months before operation were analyzed retrospectively. To investigate the correlation between HPV genotype and cervical lesions. Results among 798 cases of cervical histology, 759 cases had HPV infection, and the total positive rate was 95.11%, of which 238 cases were mixed infection, and the mixed infection rate was 29.82%. The first five most common HPV single infection types were 16 / 52 / 583 / 53 / 51, respectively. The single type of HPV infection was the main infection in different degree of cervical lesions, and the double infection was the most in the multiple type infection, especially in the cervical cancer patients (85.71%). Conclusion the grades of cervical lesions caused by different HPV types are different. Typing detection of HPV and cervical biopsy of high-risk HPV infection patients will be helpful for early detection of cervical lesions.
【作者单位】：江苏大学附属医院妇科;
【分类号】：R737.33

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