食管腺癌中EGF的表达及临床意义和预后的关系

发布时间：2018-04-27 05:00

本文选题：食管癌 + 腺癌　；参考：《现代预防医学》2017年23期

【摘要】：目的研究讨论EGF在食管腺癌的表达情况及其与临床特征、预后的关系。方法运用免疫组织化学方法研究EGF在50例食管腺癌标本中的表达水平并分析其与患者临床病理特征及预后的相关性。结果 EGF在50例食管腺癌、癌旁组织中的阳性率分别为64%和22%。Logistic回归模型进行多因素分析,结果显示临床分期和淋巴结转移是EGF表达相关的独立因素(P0.05)本组研究三年生存率59.6%,五年生存率42.5%,预后单因素分析:有淋巴结转移的患者比无淋巴结转移的5年生存率短(P=0.010),临床分期高的比临床分期低的5年生存率短(P=0.005),EGF阳性的患者比EGF阴性患者生存时间短(P=0.041),分化程度低的比分化程度高的生存时间短(P=0.006),而与性别,年龄,肿瘤浸润程度,肿瘤大小有无烟酒史无明显相关性。结论 EGF在食管腺癌中表达增高,且该表达与食管腺癌的浸润、发展、转移呈现一种相关性,淋巴结转移、临床分期、分化程度是食管腺癌患者预后的主要因素。
[Abstract]:Objective to investigate the expression of EGF in esophageal adenocarcinoma and its relationship with clinical features and prognosis. Methods Immunohistochemical method was used to study the expression of EGF in 50 cases of esophageal adenocarcinoma and its correlation with clinicopathological features and prognosis. Results the positive rate of EGF in 50 cases of esophageal adenocarcinoma was 64% and the 22%.Logistic regression model was used for multivariate analysis. The results showed that clinical staging and lymph node metastasis were independent factors associated with EGF expression (P0.05) the three-year survival rate was 59.6, and the 5-year survival rate was 42.5. The prognostic univariate analysis showed that the patients with lymph node metastasis were more likely to be 5 years old than those without lymph node metastasis. The survival rate of patients with high clinical stage was lower than that of patients with EGF negative. The survival time of patients with high clinical stage was shorter than that of patients with EGF negative, and the survival time of patients with low differentiation and high score was shorter than that of patients with EGF negative. Age, tumor invasion degree, tumor size and history of alcohol and tobacco had no significant correlation. Conclusion the expression of EGF is increased in esophageal adenocarcinoma, and this expression is correlated with the invasion, development and metastasis of esophageal adenocarcinoma. Lymph node metastasis, clinical stage and differentiation are the main prognostic factors of esophageal adenocarcinoma.
【作者单位】：河南科技大学第一附属医院;
【分类号】：R735.1

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